You Searched For: Van Der Voort Lucht en Milieu Amste

Supplier: Adipogen

Description: New class of highly photostable, water soluble fluorescent labels with large Stoke's shift, high QY in aqueous media and pH tolerance. Major disadvantage: rel. low extinction coefficient.

Supplier: Adipogen

Description: Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

Catalog Number: (102513-322)

Supplier: Adipogen

Description: Human DR3 (TRAMP; LARD) was designated TNF receptor superfamily member 25. TL1A is a ligand which can induce apoptosis through a cytoplasmic death domain similar to the CD178-CD95 (FasL-Fas) interaction. Alternatively, engagement of DR3 on T cells can synergize with other activating signals to enhance IFNgamma production.

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Supplier: Adipogen

Description: Antibiotic. Antiprotozoal. Antimicrobial. Cytotoxic and genotoxic in various mammalian cells. Mitochondrial permeability transition pore (MPTP) activator. Apoptosis inducer. ERK and JNK signaling pathways activator. Nephrotoxic mycotoxin. Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways. Tubulin polymerization and mitotic spindle assembly inhibitor. Increases reactive oxygen species (ROS). Induces cell cycle arrest at the G0/G1 and G2/M phase.

Catalog Number: (102513-474)

Supplier: Adipogen

Description: Nucleoside antibiotic. Antitumor compound. Xanthosine monophosphate (XMP) aminase inhibitor. RNA synthesis inhibitor. Specific GMP synthase inhibitor. Reduces intracellular GTP levels.

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Catalog Number: (102513-180)

Supplier: Adipogen

Description: TNF (Tumor necrosis factor; cachexin; cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction.

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Catalog Number: (102512-138)

Supplier: Adipogen

Description: Human CD23 is a low affinity receptor for IgE (Fc epsilon RII) found primarily on mature B cells and also on eosinophils, monocytes, dendritic cells, platelets and a subset of thymic epithelial cells. CD23 interacts with CD21.

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Supplier: Adipogen

Description: Major naproxen demethylation metabolite. Naproxen demethylation is mediated primarily by CYP2C9. Can be used for assaying naproxen metabolites.

Supplier: Adipogen

Description: ANGPTL3 (Angiopoietin-like protein 3) regulates angiogenesis and also directly regulates lipid, glucose, and energy metabolism.

Supplier: Adipogen

Description: PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.

Supplier: Adipogen

Description: Anthralin is a leukotriene biosynthesis inhibitor. It inhibits LTB4 omega-oxidation and disrupts mitochondria function. Anthralin is used in the treatment of psoriasis, as a fungicide, in the treatment of ringworm infections and in chronic dermatoses. It accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. Numerous studies have demonstrated anti-proliferative and anti-inflammatory effects of anthralin on psoriatic and normal skin. It is also used as matrix substance for MALDI-MS (matrix-assisted laser desorption ionization MS).

Supplier: Adipogen

Description: Quorum sensing agent.

Supplier: Adipogen

Description: Glutathione peroxidase 3 (GPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the diagnosis of clear cell type ovarian adenocarcinoma.

Catalog Number: (102513-216)

Supplier: Adipogen

Description: Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation. CD137 is a type I membrane protein and a member of the TNF receptor superfamily. CD137 appears to be important for T cell proliferation and survival and induces monocyte activation.

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Catalog Number: (102512-050)

Supplier: Adipogen

Description: Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages and a subset of granulocytes. CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein. A soluble form of CD14 also binds to LPS and LBP.

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Supplier: Adipogen

Description: APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.