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Description: Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterized by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.

Catalog Number: 102980-250

Supplier: Adipogen

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Description: Human CD49d molecules are integrin alpha4 chains that are expressed as heterodimers with CD29 (beta 1 integrin) or (beta 7 integrin) and function as adhesion receptors. CD49d/CD29 is mainly expressed on thymocytes and B cells with increased expression on activated T cells. The ligands for CD49d/CD29 include VCAM-1 and fibronectin.

Catalog Number: 102512-408

Supplier: Adipogen

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Description: Potent antibiotic

Catalog Number: 102987-408

Supplier: Adipogen

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Description: Selective and cell permeable protein kinase C (PKC) inhibitor. Inhibits the stimulation of insulin secretion by glucose. Inhibits T cell activation. Apoptosis inducer. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Transcription inhibitor. Induces TNF receptor family-mediated cell death. Pim-1 kinase inhibitor. Antitumor compound.

Catalog Number: 102516-160

Supplier: Adipogen

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Description: AMCA-X SE is an amine-reactive, UV-excitable, blue fluorescent dye.

Catalog Number: 102989-186

Supplier: Adipogen

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Description: Human CD105 (endoglin) is a homodimeric membrane glycoprotein virtually restricted to endothelial cells and present on some leukemia cells and minor subsets of bone marrow cells. CD105 binds to TGF-beta1 and beta3 with high affinity.

Catalog Number: 102512-974

Supplier: Adipogen

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Description: Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF-R signaling is essential for B cell development, survival and humoral immune responses.

Catalog Number: 102514-330

Supplier: Adipogen

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Description: Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naïe CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.

Catalog Number: 102513-894

Supplier: Adipogen

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Description: Human CD270 (Herpes Virus Entry Mediator; TNFRSF14; ATAR; LIGHTR; TR2) is a 36kDa type I membrane protein that has been found on a broad range of lymphoid tissues. Its ligands include the TNF ligand family members LTalpha and LIGHT and the CD28/Ig superfamily member BTLA.

Catalog Number: 102512-746

Supplier: Adipogen

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Description: Human CD86 (B7-2) is a costimulating ligand for CD28 and CTLA-4. CD86 is expressed on activated B cells and blood monocytes.

Catalog Number: 102512-904

Supplier: Adipogen

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Description: Human CD69 is expressed by platelets and mature thymocytes and appears rapidly after activation on T cells, B cells and NK cells. This pattern of cellular CD69 expression has suggested a lymphocyte activation role. Functional studies with antibodies to CD69 also support an activation role for CD69.

Catalog Number: 102512-548

Supplier: Adipogen

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Description: NDSB-256-4T is a non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates protein-folding, presumably by interacting with the early folding intermediates. Shown to improve the in vitro renaturation efficiency of reduced hen lysozyme and chemically unfolded tryptophan synthase beta2 subunit.

Catalog Number: 102989-368

Supplier: Adipogen

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Description: Chirality inducing agent. Useful tool as resolving agent to separate the isomers and purify racemic mixtures (e.g. DL-lysine) by fractionally crystallizing the product to obtain the pure isomer (e.g. D-lysine). Can also be used as building block.

Catalog Number: 102989-498

Supplier: Adipogen

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Description: Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

Catalog Number: 102514-074

Supplier: Adipogen

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Description: CD137 is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.

Catalog Number: 102514-430

Supplier: Adipogen

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Description: ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.

Catalog Number: 102514-376

Supplier: Adipogen

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