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Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2a antibody against human, mouse F4/80, PerCP-Cy5.5-conjugated.

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Catalog Number: (MSPP-01994)
Supplier: Stemcell Technologies
Description: For detection and measurement of human immunoglobulin G.

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Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2b antibody against mouse CD24, PE-conjugated.

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Catalog Number: (MSPP-60018PS)
Supplier: Stemcell Technologies
Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD45, PerCP-Cy5.5-conjugated.

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Catalog Number: (MSPP-19061)
Supplier: Stemcell Technologies
Description: Immunomagnetic isolation of untouched human myeloid dendritic cells (mDCs).


Catalog Number: (MSPP-19856)
Supplier: Stemcell Technologies
Description: Immunomagnetic isolation of untouched mouse stem/progenitor cells


Catalog Number: (MSPP-78030)
Supplier: Stemcell Technologies
Description: Interleukin 13 (IL-13) is a type I cytokine, and signals through type I cytokine receptors to activate JAK/STAT and IRS-1/IRS-2 pathways. IL-13 is produced by T cells and innate lymphoid cells (Pulendran and Artis) and it inhibits production of pro-inflammatory cytokines, prostaglandins, and reactive oxygen and nitrogen species by monocytes and macrophages (Hershey). Unlike human B cells, IL-13 has no effect on mouse B cell development and function. IL-13 promotes eosinophil survival, activation, and recruitment, and also activates mast cells (Hershey). IL-13 regulates gastrointestinal parasite expulsion, airway hyperresponsiveness, allergic inflammation, tissue eosinophilia, goblet cell hyperplasia, intracellular parasitism, tissue remodeling, tumor cell growth, and fibrosis. IL-13 induces hypercontractility of smooth muscles by directly acting on the muscle cells as well as the enteric nerves (Wynn).

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Supplier: Stemcell Technologies
Description: Brain-derived neurotrophic factor (BDNF), like nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), is a member of the NGF family of neurotrophins, which are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems (Minichiello and Klein; Minichiello <i>et al.</i>). BDNF binds with high affinity to the tropomyosin receptor kinase B (TrkB), and activates AKT and ERK pathways (Mattson <i>et al.</i>). It is expressed in the hippocampus, cortex, and synapses of the basal forebrain. BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle <i>et al.</i>). BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, and contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, and homeostatic regulation of neuronal excitability (Reichardt). It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder and Scharfman). BDNF, together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman).

Catalog Number: (MSPP-781452)
Supplier: Stemcell Technologies
Description: Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

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Catalog Number: (MSPP-05985)
Supplier: Stemcell Technologies
Description: Serum-containing supplement for the expansion of mouse skeletal muscle progenitor cells (satellite cells).

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Catalog Number: (MSPP-19663)
Supplier: Stemcell Technologies
Description: Immunomagnetic isolation of CD8+ T cells directly from whole blood


Catalog Number: (MSPP-15272HLA)
Supplier: Stemcell Technologies
Description: Immunodensity isolation of untouched myeloid cells for lineage-specific chimerism analysis.


Catalog Number: (MSPP-100-0195)
Supplier: Stemcell Technologies
Description: Serum-free media for generation and maturation of branching lung organoids from human ES and iPS cells.


Supplier: Stemcell Technologies
Description: Mouse monoclonal IgG3, kappa isotype control antibody, Alexa Fluor® 488-conjugated.

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Catalog Number: (MSPP-07461)
Supplier: Stemcell Technologies
Description: For hydrolysis of hyaluronic acid.

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Catalog Number: (MSPP-02694)
Supplier: Stemcell Technologies
Description: Serum-free culture supplement for expansion and differentiation of human monocytes.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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