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Description: Immunomagnetic negative selection of human pan-B cells
Catalog Number: MSPP-19554RF
Supplier: Stemcell Technologies


Description: Immunomagnetic isolation of untouched human CD8+ T cells.
Catalog Number: MSPP-100-0710
Supplier: Stemcell Technologies


Description: Immunomagnetic isolation of untouched non-human primate CD4+ T cells
Catalog Number: MSPP-19582
Supplier: Stemcell Technologies


Description: 15 ml centrifuge tube with an insert for density gradient centrifugation
Catalog Number: MSPP-85415
Supplier: Stemcell Technologies


Description: Immunomagnetic isolation of untouched rat CD4+ T cells
Catalog Number: MSPP-19642
Supplier: Stemcell Technologies


Description: Immunomagnetic positive selection of mouse cells labeled with biotinylated antibodies.
Catalog Number: MSPP-17665
Supplier: Stemcell Technologies


Description: Immunomagnetic negative selection kit
Catalog Number: MSPP-19863
Supplier: Stemcell Technologies


Description: Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson <i>et al.</i>). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda <i>et al.</i>). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon <i>et al.</i>). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey <i>et al.</i>). RANKL is involved in osteoclastogenesis (Lacey <i>et al.</i>; Yasuda <i>et al.</i>) and T cell activation (Wong <i>et al.</i>). This product is animal component-free.
Catalog Number: MSPP-78215
Supplier: Stemcell Technologies


Description: R-Spondin-1 (RSPO1) is the prototype member of the R-Spondin (RSPO) protein subfamily of a superfamily of thrombospondin type 1 repeat (TSR-1)-containing proteins (Chen <i>et al.</i>; Kamata <i>et al.</i>; Kazanskaya <i>et al.</i>; Kim <i>et al.</i>). Although unable to initialize signaling, RSPO family members are potent enhancers of WNT signaling (Cruciat and Niehrs; de Lau <i>et al.</i>; Kamata <i>et al.</i>; Kazanskaya <i>et al.</i>). They are characterized by a TSR-1 domain, a carboxy-terminal region with positively charged amino acids, and two N-terminal furin-like cysteine-rich repeats (Glinka <i>et al.</i>; Kazanskaya <i>et al.</i>). R­-Spondin-1 activates β­-catenin signaling via the WNT signaling cascade and by indirectly increasing low-density lipoprotein receptor-related protein 6 (LRP6) on the cell surface. It does this by binding leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), and competing with WNT antagonist DKK­1 for binding to the WNT co­receptors, Kremen and LRP­6, which reduces DKK­1-­mediated internalization of LRP6 (Binnerts <i>et al.</i>). RSPO1 is involved in a wide range of pleiotropic roles during embryogenesis, it is required for the specification of hematopoietic stem cells, and it has been shown to be important in the growth, survival, and migration of ovarian cancer cells (Cruciat and Niehrs; de Lau <i>et al.</i>; Genthe and Clements; Liu <i>et al.</i>).
Catalog Number: MSPP-782131006
Supplier: Stemcell Technologies


Description: A solution containing sodium salts of dATP, dCTP, dGTP and dTTP, each at 10 mM.
Catalog Number: MSPP-76027
Supplier: Stemcell Technologies


Description: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD2, APC-conjugated.
Catalog Number: MSPP-60007AZ1
Supplier: Stemcell Technologies


Description: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD138 (syndecan-1), unconjugated.
Catalog Number: MSPP-60003
Supplier: Stemcell Technologies


Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils, and basophils) and monocytic lineages <i>in vivo</i>. It has been tested for mobilization of hematopoietic progenitor cells and used to treat chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>).
Catalog Number: MSPP-781902
Supplier: Stemcell Technologies


Description: Rat monoclonal IgM antibody against mouse CD49b (integrin α2), APC-conjugated.
Catalog Number: MSPP-60020AZ
Supplier: Stemcell Technologies


Description: Mouse monoclonal IgG2b, kappa isotype control antibody, FITC-conjugated.
Catalog Number: MSPP-60072FI1
Supplier: Stemcell Technologies


Description: Rat monoclonal IgG2b antibody against mouse CD25, FITC-conjugated.
Catalog Number: MSPP-60010FI1
Supplier: Stemcell Technologies


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