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Supplier: Stemcell Technologies
Description: Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

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Catalog Number: (MSPP-781970)
Supplier: Stemcell Technologies
Description: Indian hedgehog (IHH) is one of three proteins in the hedgehog family which includes sonic hedgehog and desert hedgehog. Hedgehog proteins are important signaling molecules, acting through patched and smoothened receptors. During embryonic development, they are expressed in the fetal lung, gut, stomach, liver, kidney, and pancreas. IHH is strongly expressed in cartilage and regions of developing bone, and its signaling regulates growth and differentiation of bone tissue (Marigo <i>et al.</i>; Valentini <i>et al.</i>; St-Jacques <i>et al.</i>). IHH is also involved in yolk sac vasculogenesis, indicating a role in the differentiation of epiblast cells into endothelial and red blood cells (Byrd <i>et al.</i>). IHH induces the expression of parathyroid hormone-related peptide (PTHrP), which negatively regulates IHH during chondrocyte differentiation and proliferation (Vortkamp <i>et al.</i>).

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Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2a antibody against mouse CD4, PE-conjugated.

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Catalog Number: (MSPP-100-0214)
Supplier: Stemcell Technologies
Description: Cell culture medium for further differentiation of human intestinal organoids in 3D, or as monolayers/air-liquid interface cultures.


Catalog Number: (MSPP-05965)
Supplier: Stemcell Technologies
Description: Medium for the differentiation of human skeletal muscle progenitor cells (myoblasts) into myotubes.

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Catalog Number: (MSPP-100-0711)
Supplier: Stemcell Technologies
Description: Culture medium kit for expansion of human NK cells.


Catalog Number: (MSPP-03817)
Supplier: Stemcell Technologies
Description: Chemically defined, animal component-free, serum-free, protein-free, glutamine-free liquid medium for culture of CHO cells.

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Catalog Number: (MSPP-60030BT1)
Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2b antibody against mouse CD45, biotin-conjugated.

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Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2a antibody against human, mouse, rhesus CD49f, Alexa Fluor® 488-conjugated.

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Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b, PerCP-Cy5.5-conjugated.

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Catalog Number: (MSPP-17846)
Supplier: Stemcell Technologies
Description: Immunomagnetic positive selection of human EpCAM+ cells (e.g. mammary epithelial cells).


Supplier: Stemcell Technologies
Description: Mouse monoclonal IgG2a antibody against human, mouse, rat beta-tubulin III, Alexa Fluor® 488-conjugated.

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Supplier: Stemcell Technologies
Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD33, PE-conjugated.

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Catalog Number: (MSPP-78163)
Supplier: Stemcell Technologies
Description: Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick <i>et al.</i>). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata <i>et al.</i>).

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Catalog Number: (MSPP-60063FI)
Supplier: Stemcell Technologies
Description: Mouse monoclonal IgG1 antibody against human SSEA-5, FITC-conjugated.

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Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2a antibody against mouse CD19, PerCP-Cy5.5-conjugated.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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