You Searched For: DIAGNOSTIC BIOSYSTEMS INC

Supplier: Diagnostic Biosystems

Description: Epithelial antigen is a cell surface glycoprotein and is broadly distributed in epithelial cells and displays a highly conserved expression in carcinomas. Epithelial antigen has been shown to play an important role as a tumor cell marker in lymph nodes from patients with esophageal carcinoma. Epithelial antigen can be used to distinguish between basal cell and basosquamous carcinomas and squamous cell carcinoma of the skin.

Supplier: Diagnostic Biosystems

Description: Napsin is found in two isoforms, A and B, with highly homologous gene sequences. Napsin A has a molecular weight of 35.0 kDa and is also known as TA02. Napsin A is an aspartic proteinase which is expressed in the lung and involved in processing surfactant protein B (SP-B). It is also expressed in the kidney. This antibody may be a useful tool as a tumor marker for primary lung adenocarcinoma. Napsin expression correlates with the differentiation grade of lung adenocarcinoma.

Catalog Number: (76634-362)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes cytokeratin polypeptides ranging from 40 through 58kDa, corresponding to cytokeratins 5, 6, 8,17 and 19. It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelia to stratified squamous epithelia, like epidermis, mammary gland ducts and tracheal epithelium.

Sale

Supplier: Diagnostic Biosystems

Description: This antibody recognizes keratin polypeptide of 54 kDa. It stains strongly with non-squamous epithelium but does not stain squamous epithelium. It reacts with the sweat gland and ducts in the skin. Adenocarcinomas of the ovary, gastrointestinal tract, ductal carcinoma of breast, pancreas and bile ducts, stain positive with this antibody.

Supplier: Diagnostic Biosystems

Description: The catenins are structurally related cytoplasmic proteins which have been classified as alpha (α), beta (β), and gamma (γ), these proteins can bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule.

Catalog Number: (76634-314)

Supplier: Diagnostic Biosystems

Description: Alpha fetoprotein (AFP) is a single chain glycoprotein of 70 kDa that is normally expressed in the fetal liver, gastrointestinal tract and yolk sac. This antibody recognizes an epitope of α-fetoprotein present in human and several other species.

Sale

Catalog Number: (99990-072)

Supplier: Diagnostic Biosystems

Description: Alkaline phosphatase enhancer is a ready to use stable solution designed to increase the signal generated by alkaline phosphatase several fold. A single treatment of tissue sections with enhancer before the treatment with substrate/chromogen enables the visualization of difficult to localize antigens.

Sale

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a protein of 110 kDa, identified as androgen receptor. This antibody reacts with full length AR and also with the newly described A form of the receptor. This antibody does not cross-react with estrogen, progesterone or glucocorticoid receptors.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with the heavy chain present in all types of human IgM. It stains B cell follicles in human lymphoid tissues. In lymphoid tissues, IgM containing plasma cells stain strongly but immune complexes are usually undetectable.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes keratin polypeptide of 54 kDa. It stains a number of epithelial cells including ductal and glandular epithelia. Stratified squamous epithelia are positive but transitional epithelium of the urinary tract does not show any staining. This antibody labels adenocarcinomas and transitional carcinomas but does not react with squamous cell carcinomas.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to an oncofetal antigen of >1,000 kDa known as tumor associated glycoprotein (TAG-72) or CA 72-4. This antibody defines the mucin carried sialylated-Tn antigen. This antibody stains the majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 220 kDa protein. CD15 plays a role in mediating phagocytosis, bactericidal activity and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is also expressed in Reed-Sternberg cells and some epithelial cells. CD15 is very useful in the identification of Hodgkin disease.

Supplier: Diagnostic Biosystems

Description: The G168-15 antibody recognizes human and mouse MLH1 (80 to 85 kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 34 kDa protein known as calponin. Calponin, a calmodulin, binds tropomyosin and F-actin and is thought to be involved in the regulation of smooth muscle contraction. Expression of calponin is restricted to smooth muscle cells. Two isoforms of calponin exist whose molecular weights are 34 KD and 29 kDa. 29 kDa isoform is primarily restricted to the muscle of the urogenital tract.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.

Catalog Number: (76633-066)

Supplier: Diagnostic Biosystems

Description: PermaRed/HRP is a substrate-chromogen system designed to be used for either IHC or ISH when utilizing horseradish peroxidase. PermaRed/HRP produces a distinct brick red stain that can easily be distinguished from other stains.

Sale