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Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 100 kDa glycoprotein expressed by endothelial cells and 130 kDa glycoprotein present in platelets. It stains endothelial cells in normal as well as malignant tissues.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with human isoenzymes of neuron specific enolase containing γ subunits. This antibody gives a specific staining in neurons of the brain, in islets of Langerhans in pancreas and in peripheral nerves of the skin. No staining with other tissue types has been seen.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes cytokeratin polypeptides ranging from 40 through 58kDa, corresponding to cytokeratins 5, 6, 8,17 and 19. It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelia to stratified squamous epithelia, like epidermis, mammary gland ducts and tracheal epithelium.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.

Catalog Number: (10065-004)

Supplier: Diagnostic Biosystems

Description: PAX 8 is expressed in a high percentage of renal cell carcinomas and ovarian cancers. This mouse monoclonal PAX 8 antibody [BC12] has been designed to target restricted epitopes, and exhibits higher specificity and provides sharper staining than the PAX 8 rabbit polyclonal antibody. Unlike the polyclonal PAX 8, this mouse monoclonal antibody does not stain B-cells, and does not recognize epitopes of pancreatic origin and neuroendocrine cells in stomach and colon; thus providing superior specificity. The expression of the mouse monoclonal PAX 8 targets antigens found in normal kidney, thyroid and cervix, but not normal ovary. PAX 8 stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded tissues.

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Catalog Number: (76633-186)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.

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Catalog Number: (76634-402)

Supplier: Diagnostic Biosystems

Description: The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has been shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.

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Supplier: Diagnostic Biosystems

Description: This antibody reacts with a glycoprotein of MW 110 kDa, present on the surface of hematopoietic cells i.e. myeloid and lymphoid progenitors. It stains the vascular endothelial cells.

Supplier: Diagnostic Biosystems

Description: Mesothelin is a glycocylphosphotidylianositol-linked cell-surface glycoprotein, which is present on the surface of normal mesothelium and is overexpressed in many patients with epithelial ovarian cancer and malignant mesotheliomas.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 160 kDa protein known as Factor XIII-A. Factor XIII is a β-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and v variable reaction with these types of tumors.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 110kDa human CD57 myeloid associated glycoprotein. It stains mononuclear cells with natural killer activity, neuroendocrine cells and their tumors.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to human CD79a antigen complex, consisting of two polypeptides non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of polypeptide and immunoglobulins constitute the B cell antigen receptor. The two components of this complex are designated CD79a and CD79b. The CD79a antigen appears at the Pre-B cell stage, early in maturation and persists until the plasma cell stage. The CD79a antigen is found in majority of acute leukemias of precursor B cell type, in B cell lines and B cell lymphomas.

Catalog Number: (76634-176)

Supplier: Diagnostic Biosystems

Description: PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis ). Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathway related to human malignant tumors. Studies have demonstrated a reduction of PTEN expression in advanced breast cancers.

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Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 38 kDa protein. Synaptophysin is an glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, retina, vesicles of adrenal medulla and in neuromuscular junctions. This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types.

Supplier: Diagnostic Biosystems

Description: This antibody is specific for α-skeletal muscle actinin and α-cardiac actinin. It stains Z lines and dots in stress fibers of myotubes in skeletal and cardiac muscle but not in non-sarcomeric muscle elements.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes the CD8. The CD8 molecule consists of two chains, α and β, which are expressed as a disulphide-linked α/β heterodimer or as an α/α homodimer on T cell subset, thymocytes and NK cells. The majority of CD8+ T cells express CD8 as α/β heterodimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α chain (but not β chain).