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Description: This antibody reacts with the heavy chain present in all types of human IgM. It stains B cell follicles in human lymphoid tissues. In lymphoid tissues, IgM containing plasma cells stain strongly but immune complexes are usually undetectable.
Catalog Number: 99990-898
Supplier: Diagnostic Biosystems


Description: This antibody stains with ORF-73 of human herpesvirus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene ORF 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity.
Catalog Number: 76634-506
Supplier: Diagnostic Biosystems


Description: The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has been shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.
Catalog Number: 76633-880
Supplier: Diagnostic Biosystems


Description: Multiple myeloma oncogene-1 (MUM1) is a 50 kDa protein encoded by the MUM1 gene. This antibody stains MUM1 protein, which is expressed in a subset of B cells in the light zone of the germinal center, plasma cells, activated T cells and a wide spectrum of related hematolymphoid neoplasms. This antibody is useful in the sub classification of lymphoid malignancies.
Catalog Number: 76634-508
Supplier: Diagnostic Biosystems


Description: Clone number KP1, This antibody is specific to macrophages in a wide variety of human tissues. It reacts with myeloid precursors and peripheral blood granulocytes. It also stains a cell population known as Plasmacytoid T cells.
Catalog Number: 99990-370
Supplier: Diagnostic Biosystems


Description: This antibody reacts with cow S-100 protein a and b. It shows strong cross-reactivity with human S-100 a and b. In the brain, it labels glial and ependymal cells. Melanocytes and Langerhans cells of the skin stain positive with this antibody.
Catalog Number: 99991-056
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a 49 kDa protein. At least five CD1 genes are identified (CD1a, b, c, d and e). This antibody reacts with cortical thymocytes, Langerhans cells in epidermis, dendritic cells of dermis and Langerhans cells of mucosa of tonsil. This antibody may be useful in the characterization of leukemias and lymphomas.
Catalog Number: 99990-678
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a nuclear antigen present in proliferating human cells. It can be used to evaluate the Ki-67 labeling index in various tumors.
Catalog Number: 99991-248
Supplier: Diagnostic Biosystems


Description: Clone number 6F-H2, Wilms' Tumor (WT1), is a gene involved in the induction of Wilms? tumor, a pediatric renal malignancy. Wilms' tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system.
Catalog Number: 95024-886
Supplier: Diagnostic Biosystems


Description: This antibody is specific to 34 kDa protein known as myogenin. Myogenin is a member of family of myogenic regulatory genes which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors which are essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin.
Catalog Number: 99990-602
Supplier: Diagnostic Biosystems


Description: This antibody is a member of a family of complex antigens, which also includes non-specific cross-reacting antigens (NCA). This antibody stains specific regions of CEA. It reacts with colorectal adenocarcinomas but does not show any staining with polymorphonuclear neutrophils and erythrocytes.
Catalog Number: 76633-104
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a 70 kDa protein. COX-2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters and cytokines that induce its expression. COX-2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX-1 levels remained unchanged.
Catalog Number: 95024-978
Supplier: Diagnostic Biosystems


Description: This antibody recognizes a 200 kDa glycoprotein (GP200) localized in the brush border of the proximal renal tebules and the luminal surface of Bowman’s capsule. GP200 was expressed by 93% of primary and 84% of metastatic renal carcinomas. GP200 glycoprotein is also localized in the breast lobules and ducts, parathyroid glands and epididymis.
Catalog Number: 76633-964
Supplier: Diagnostic Biosystems


Description: This antibody is specific to γ-γ enolase isozyme of 46 kDa. This antibody stains neurons, neuroendocrine cells, gangliomas, oat cell carcinomas, astrocytomas, paragangliomas, glioblastomas, pheochromocytomas, melanomas and schwannomas.
Catalog Number: 76635-076
Supplier: Diagnostic Biosystems


Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.
Catalog Number: 76634-554
Supplier: Diagnostic Biosystems


Description: MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-base mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
Catalog Number: 76634-404
Supplier: Diagnostic Biosystems


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