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Catalog Number: (95027-200)

Supplier: Diagnostic Biosystems

Description: This kit stains ferric iron in paraffin tissue sections

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Catalog Number: (76634-686)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with HSV type I and II specific antigens and with antigens common to HSV type I and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein.

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Supplier: Diagnostic Biosystems

Description: This antibody recognizes collagen type IV epitope located on the α1 and/or α 2 chains of human collagen type IV. This antibody shows no cross-reactivity with collagen types I, II, III, V, VI and VII and does not react with human vitronectin, fibronectin or chondroitin sulfate A, B and C.

Catalog Number: (10065-090)

Supplier: Diagnostic Biosystems

Description: The combined detection of p504S, p40 and high molecular weight cytokeratin markers has been shown to be useful for distinguishing benign conditions mimicking cancer from prostate carcinomas. In particular, these markers have been shown to be relevant in diagnosing the premalignant condition, prostatic intraepithelial neoplasia (PIN). High molecular weight cytokeratin and p63 are commonly used markers of basal epithelial cells. Benign prostate tissue contains basal cells, which are absent in prostate cancers. As p40 is an isoform of p63, it also stains basal epithelial cells and can be used in prostate cancer tissue. P504S has been recently described as a prostate cancer-specific gene. Expression of p504S (AMACR) protein is seen in prostatic adenocarcinoma but not in benign prostatic tissue. Anti-p540S stains premalignant lesions of prostate: high-grade PIN and atypical adenomatous hyperplasia. The PIN5 antibody combination may be particularly useful for confirming the diagnosis of prostate carcinoma in small foci of needle biopsies. The positive prostate cancer marker, p504S (AMACR), in conjunction with the negative basal cell markers (p40 and HMW cytokeratin) offers utility in diagnosing PIN in difficult cases where tissue may be limited.

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Catalog Number: (76634-350)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to an oncofetal antigen of >1000 kDa known as tumor associated glycoprotein (TAG-72) or CA 72-4. This antibody defines the mucin carried sialylated-Tn antigen. This antibody stains the majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer.

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Supplier: Diagnostic Biosystems

Description: This antibody is specific to human cytokeratin 18 of 45 kDa. Cytokeratin 18 belongs to a family of acidic type A keratins and exists along with cytokeratin 8 in most simple ductal and glandular epithelia. This antibody does not react with squamous epithelium. It reacts with benign and malignant epithelial lesions as well as a majority of adenocarcinomas and basal cell carcinomas.

Catalog Number: (99991-172)

Supplier: Diagnostic Biosystems

Description: Clone number SP7, The CD3 antigen is present on early thymocytes and mature T cells and is generally regarded as a Pan T cell marker. This antibody will help detect CD3 expression in normal and neoplastic tissues. This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells.

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Catalog Number: (76634-872)

Supplier: Diagnostic Biosystems

Description: The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract.

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Catalog Number: (76634-364)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes keratin polypeptide of 54 kDa. It stains strongly with non-squamous epithelium but does not stain squamous epithelium. It reacts with the sweat gland and ducts in the skin. Adenocarcinomas of the ovary, gastrointestinal tract, ductal carcinoma of breast, pancreas and bile ducts, stain positive with this antibody.

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Supplier: Diagnostic Biosystems

Description: Mono AEC/Plus is a liquid substrate chromogen system for use with horseradish peroxidase (HRP) detection in immunohistochemistry (IHC) or <i>in situ</i> hybridizations (ISH).

Catalog Number: (95027-172)

Supplier: Diagnostic Biosystems

Description: This kit stains strongly sulfated mucosubstances

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Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with Sialyl Lewis A and recognizes an epitope being designated CA 19-9. It does not cross-react with Lewis A and Lewis B. CA 19-9 has been shown to be useful marker in the diagnosis and management of gastrointestinal cancers.

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with sialyl Lewisa and recognizes an epitope being designated CA 19-9. It does not cross-reacts with Lewisa and Lewisb. CA 19-9 has been shown to be useful marker in the diagnosis and management of gastrointestinal cancers.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes insoluble elastin, α-elastin, soluble non-cross linked precursor of elastin (tropoelastin). Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues.

Catalog Number: (76634-546)

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with sialyl Lewisa and recognizes an epitope being designated CA 19-9. It does not cross-reacts with Lewisa and Lewisb. CA 19-9 has been shown to be useful marker in the diagnosis and management of gastrointestinal cancers.

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Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 92 kDa protein, known as β-catenin. The catenins (α, β and γ) are ubiquitously expressed cytoplasmic proteins, which are associated with E-cadherin. β-catenin can also bind to APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between α-actinin and α-catenin.