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Catalog Number: (99990-104)

Supplier: Diagnostic Biosystems

Description: Elite PAP pen is a special marking pen that provides a thin film-like green-tinged hydrophobic barrier when a circle is drawn around a specimen on a slide. This water repellent barrier keeps staining reagents localized on the tissue sections, prevents mixing of reagents when differentially staining two sections on the same slide, and allows use of less reagents per section. Insoluble in alcohol and acetone, PAP Pen markings can be optionally removed with xylene after the staining procedure is complete.

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Catalog Number: (95025-252)

Supplier: Diagnostic Biosystems

Description: Elite mini PAP pen is a special marking pen that provides a thin film-like green-tinged hydrophobic barrier when a circle is drawn around a specimen on a slide. This water repellent barrier keeps staining reagents localized on the tissue sections, prevents mixing of reagents when differentially staining two sections on the same slide, and allows use of less reagents per section.

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Supplier: Diagnostic Biosystems

Description: This antibody recognizes Chromogranin A. Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

Supplier: Diagnostic Biosystems

Description: The G168-15 antibody recognizes human and mouse MLH1 (80-85kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with CA 125 ovarian cancer antigen. Several studies have shown that CA 125 is a useful tumor marker for ovarian epithelial malignancies. However, CA 125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 32 kDa protein, which is identified as Caspase 3. Caspase 3 is associated with induction of apoptosis. Caspase 3 is ubiquitously expressed and is synthesized as an inactive proenzyme.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.

Catalog Number: (76634-856)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a membrane glycoprotein of 45 kDa, designated as CD23. CD23 is found on a subpopulation of peripheral blood cells, B lymphocytes and on EBV transformed B lymphoblastoid cell lines. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocytic leukemias.

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Supplier: Diagnostic Biosystems

Description: This antibody reacts with herpes simplex virus type 2. It is specific for the viral glycoprotein D (gD) protein.

Supplier: Diagnostic Biosystems

Description: This buffer is a concentrated antigen unmasking solution and is free from heavy metals

Catalog Number: (76633-310)

Supplier: Diagnostic Biosystems

Description: This antibody is specific against an epitope located on the β chain (i.e., in S-100a and S-100b) but not on the α chain of S-100 (i.e., in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

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Supplier: Diagnostic Biosystems

Description: Cloneac-1A1 .5Ml

Catalog Number: (76634-310)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with free as well as bound kappa light chains. Contaminating antibodies have been removed by solid phase adsorption.

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Supplier: Diagnostic Biosystems

Description: P504S has been recently described as a prostate cancer-specific gene that encodes a protein involved in the β-oxidation of branched chain fatty acids. Expression of p504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 160 kDa protein known as Factor XIII-A. Factor XIII is a β-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and v variable reaction with these types of tumors.

Supplier: Diagnostic Biosystems

Description: Anti-Cytokeratin (CAM 5.2) reagent has a primary reactivity with human keratin proteins that correspond to Moll’s peptides #7 and #8, Mr 48 and 52 kilodaltons (kd), respectively. Cytokeratin 7 and 8 are present on secretory epithelia of normal human tissue but not onstratified squamous epithelium. Anti-Cytokeratin (CAM 5.2) stains most epithelial-derived tissue, including liver, renal tubular epithelium, and hepatocellular and renal cell carcinomas. Anti-Cytokeratin (CAM 5.2) might not react with some squamous cell carcinomas.