You Searched For: 102855-162

Description: This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75884-926

Supplier: Biotium

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Description: Anti-IgG Goat Polyclonal Antibody (CF™ 514)

Catalog Number: 89493-540

Supplier: Biotium

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Description: This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75884-886

Supplier: Biotium

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Description: This antibody recognizes a 66 kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75977-312

Supplier: Biotium

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Description: Involucrin, Monoclonal antibody, Clone: IVRN/827, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Purified involucrin from human keratinocytes, Synonyms: IVL, Application: Immunofluorescence, Flow cytometry, Size: 500uL

Catalog Number: 75954-452

Supplier: Biotium

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Description: Glycophorin A / CD235A, Monoclonal antibody, Clone: GPHN02, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: purified, Immunogen: Human erythrocytes treated with neuraminidase, Synonyms: Blood group-MN locus; GPA; GPErik, GPSAT, Size: 100uL

Catalog Number: 75949-498

Supplier: Biotium

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Description: This antibody reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Catalog Number: 75977-900

Supplier: Biotium

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Description: PLAP (Placental Alkaline Phosphatase), Monoclonal antibody, Clone: ALPP/238, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF405S, Immunogen: Recombinant full-length human ALPP protein, Application: IF, Immunohistology (formalin), Flow, Size: 500uL

Catalog Number: 75970-352

Supplier: Biotium

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Description: Calponin-1 Monoclonal antibody, Clone: CALP + CNN1/832, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, K, Conjugate: BSA-free, Immunogen: Recom full-length human CNN1 ; Crude human uterus extract, Synonyms: CNN1, Cnn1, Application: IF, Size: 50 uL

Catalog Number: 75885-508

Supplier: Biotium

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Description: CF® dye labeled dextrans could be used as a fluorescent fluid-phase markers to study cell permeability, endocytosis, or mechanisms of biomolecular delivery. The dextran is 70,000 MW, and contains a formaldehyde-fixable free-amine group.

Catalog Number: 76221-476

Supplier: Biotium

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Description: CD34 Monoclonal antibody, Clone: HPCA1/763, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Immunogen: Recom full-length human HPCA1 protein, Isotype: IgG1 andIgG2b, kappa, Synonyms:Hematopoietic Progenitor Cell Antigen, Application: IF, Size: 500 uL

Catalog Number: 75894-370

Supplier: Biotium

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Description: Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, including 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8); 56.5 kDa (CK10); 53 kDa (CK13) and 45 kDa (CK18). This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75918-264

Supplier: Biotium

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Description: MCAM / MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MCAM/1101, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF488A, Immunogen: Recombinant human MCAM protein, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Catalog Number: 75960-686

Supplier: Biotium

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Description: This antibody recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Catalog Number: 75967-934

Supplier: Biotium

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Description: This antibody recognizes a glycoprotein of ~200 kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.

Catalog Number: 75971-180

Supplier: Biotium

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Description: PLAP (Placental Alkaline Phosphatase), Monoclonal antibody, Clone: GM022, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF640R, Immunogen: Recombinant full-length human ALPP protein, Application: IF, Immunohistology (formalin), Flow cytometry, Size: 500uL

Catalog Number: 75970-528

Supplier: Biotium

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