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Description: The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.

Catalog Number: 10050-562

Supplier: Tonbo Biosciences

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Description: Secondary Rabbit Anti-IgG2a Reacts with Mouse

Catalog Number: RL610-4641

Supplier: Rockland Immunochemical

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Description: Anti-CD40 is useful for Flow Cytometry. Researchers should determine optimal titers for applications that are not stated.

Catalog Number: RL200-308-N67

Supplier: Rockland Immunochemical

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Description: Host: Mouse, Isotype: IgG1

Catalog Number: 89165-674

Supplier: Enzo Life Sciences

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Description: Anti-GluR2 Antibody is suitable for use in WB, IHC, IP, and Immuno-gold EM. Expect a band approximately ~90kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Catalog Number: RL200-301-F34

Supplier: Rockland Immunochemical

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Description: IgG (H&L), Polyclonal Antibody, Host: Mouse, Target Species: Goat, Format: IgG, Label: Fluorescein (FITC) Conjugated, Immunogen: Goat IgG whole molecule, Applications: FLISA, Size: 20mg

Catalog Number: 10801-778

Supplier: Rockland Immunochemical

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Description: ImmunoReagents’ Horseradish Peroxidase (HRP) antibody conjugates are the most popular conjugates due to their high level of sensitivity, stability, and low costs. HRP conjugates are an ideal choice for use in ELISA, Immunohistochemistry (IHC), and Western blotting experiments.

Catalog Number: 10150-398

Supplier: Immunoreagents

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Description: ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

Catalog Number: 75933-712

Supplier: Rockland Immunochemical

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Description: In muscle tissue, collagen serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. A collagen may be defined as a protein containing sizable domain(s) of triple-helical conformation. Type IV collagen is a major macromolecular constituent of basement membranes and can be readily isolated from basement-membrane-rich tissues or highly vascularized tissues such as the placental villi. This collagen appears to be largely restricted to structures identifiable as basement membranes. In contrast, type VI collagen appears to be prevalent in several tissues even though it has been isolated largely from placental villi preparations. The extent to which type VII and VIII collagens are distributed is not known.

Catalog Number: 76262-770

Supplier: Rockland Immunochemical

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Description: Secondary Rabbit Anti-IgG F(ab')2 Reacts with Goat

Catalog Number: RL605-4215

Supplier: Rockland Immunochemical

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Description: Produced through a multi-stage process that includes delipidation, salt fractionation, ion-exchange chromatography, gel filtration, and affinity chromatography. No contaminating proteins are observed when assayed at a protein concentration of 20mg/mL against anti-whole serum or anti-fragment specific antisera. All immunoglobulin fragments are prepared from highly purified, whole molecules subject to enzymatic digestion.

Catalog Number: RL006-0002

Supplier: Rockland Immunochemical

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Description: Suitable for immunoblotting, ELISA, immunochemistry, immunomicroscopy as well as other antibody based assays using streptavidin or avidin conjugates requiring extremely low background levels, absence of F(c) mediated binding, lot-to-lot consistency, high titer specificity.

Catalog Number: RL810-1602

Supplier: Rockland Immunochemical

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Description: Recombinant monclonal antibody (Rat IgG2aλ).

Recommended Applications: Flow Cytometry, WB

Catalog Number: 76284-722

Supplier: Enzo Life Sciences

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Description: Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.

Catalog Number: 75933-006

Supplier: Rockland Immunochemical

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Description: This product is designed for immunofluorescence microscopy, fluorescence based plate assays (FLISA) and fluorescent western blotting. This product is also suitable for multiplex analysis, including multicolor imaging, utilizing various commercial platforms.

Catalog Number: RL711-106-002

Supplier: Rockland Immunochemical

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Description: Monoclonal Antibody, Primary Antibody, Used in ELISA, WB with species reactivity to Human, Host: Mouse, Immunogen: Recombinant human Visfatin (Nampt/PBEF) (aa 1-491), Isotype: IgG1

Catalog Number: 10049-620

Supplier: Enzo Life Sciences

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