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Description: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Catalog Number: 76634-534
Supplier: Diagnostic Biosystems


Description: This antibody is specific to a protein of 20 kDa known as MART-1 (melanoma antigen recognized by T cells-1 or Melan-A. This antibody does not cross-react with MAGE-1 or tyrosinase. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. This antibody stains melanomas and other tumors showing melanocytic differentiation.
Catalog Number: 76634-414
Supplier: Diagnostic Biosystems


Description: Chromogranin A is a 439 amino acid protein present in secretory granules of a wide variety of endocrine cells and neurons. A positive staining is seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary gland and Langerhans islets of pancreas. This antibody stains a variety of neuroendocrine tumors.
Catalog Number: 76634-324
Supplier: Diagnostic Biosystems


Description: This antibody is specific to 50 kDa cytokeratin protein designated cytokeratin 14. Cytokeratin 14 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 15. This antibody can be used to distinguish stratified epithelial cells from simple epithelial cells.
Catalog Number: 76633-902
Supplier: Diagnostic Biosystems


Description: This antibody recognizes most of the acidic (Type I) keratins. It recognizes keratin polypeptides of 50 and 56.5 kDa. In keratinized epidermis, 50 kDa keratin is present in the basal layer, while 56.5 kDa keratin is present in suprabasal layers.
Catalog Number: 76633-278
Supplier: Diagnostic Biosystems


Description: This antibody reacts with HSV type I and II specific antigens and with antigens common to HSV type I and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein.
Catalog Number: 76634-686
Supplier: Diagnostic Biosystems


Description: This antibody reacts with free as well as bound kappa light chains. Contaminating antibodies have been removed by solid phase adsorption.
Catalog Number: 99991-070
Supplier: Diagnostic Biosystems


Description: This antibody is specific to a protein of 20 kDa known as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. This antibody does not cross-react with MAGE-1or tyrosinase. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. This antibody stains melanomas and other tumors showing melanocytic differentiation.
Catalog Number: 95024-656
Supplier: Diagnostic Biosystems


Description: This antibody is specific to erythroid cells at various stages of differentiation from the erythroblast to the mature red cell.
Catalog Number: 76633-206
Supplier: Diagnostic Biosystems


Description: This antibody does not show any cross-reactivity with kappa light chain. It stains B cell follicles in human lymphoid tissues. The mantle zone shows a mosaic pattern of labeling while the germinal centers show a coarse meshwork pattern of staining.
Catalog Number: 76633-226
Supplier: Diagnostic Biosystems


Description: This antibody is specific to a 38 kDa protein. Synaptophysin is a glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, retina, vesicles of adrenal medulla and in neuromuscular junctions. This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types.
Catalog Number: 76633-810
Supplier: Diagnostic Biosystems


Description: This antibody recognizes thyroglobulin in hyperplastic and neoplastic thyroid. Thyroglobulin is a protein of 670 kDa consisting of two identical subunits. Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid.
Catalog Number: 76634-254
Supplier: Diagnostic Biosystems


Description: This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell chymase is considered to be an important marker of mast cells and is an important mediator of inflammation.
Catalog Number: 76633-726
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a 1000 kDa protein and recognizes the peptide core of gastric mucin M1. Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric mucin M1 antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or changes in the glycosylation pattern of mucin, which expose the hidden M1 antigen.
Catalog Number: 99990-668
Supplier: Diagnostic Biosystems


Description: This antibody is specific to 53 kDa protein, expressed on activated platelets. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. It is also expressed on granulocytes, B cells and T cells.
Catalog Number: 99990-564
Supplier: Diagnostic Biosystems


Description: This antibody is specific to CD74. This antibody can be used for the identification of B cell lymphomas and leukemias. It also stains activated neoplastic cells in T cell lymphomas and Sternberg-Reed cells.
Catalog Number: 99990-372
Supplier: Diagnostic Biosystems