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Description: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.
Catalog Number: 100246-398
Supplier: Southern Biotechnology


Description: Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.
Catalog Number: 100243-706
Supplier: Southern Biotechnology


Description: Goat F(ab')2 Anti-Mouse IgG(H+L)-Alexa Fluor 488 antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.
Catalog Number: 103264-386
Supplier: Southern Biotechnology


Description: Rabbit F(ab')2 Anti-Rat IgG(H+L)-AP antibody with minimal reactivity to human proteins for use in ELISA and immunocytochemistry assays.
Catalog Number: 100245-094
Supplier: Southern Biotechnology


Description: CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
Catalog Number: 100243-302
Supplier: Southern Biotechnology


Description: CD33 is a 67 kDa type I transmembrane glycoprotein and a member of the sialoadhesin family of cell surface receptors. It is absent from pluripotent stem cells but appears on myelomonocytic precursors after CD34. It then continues to be expressed on both the myeloid and monocyte lineages. While it has been reported that CD33 can function as a sialic acid-dependent cell adhesion molecule, cells expressing CD33 require desialylation before they can bind cells bearing the appropriate sialoglycoconjugates. This suggests that inhibitory cis interactions may regulate or block any adhesion function.
Catalog Number: 103265-390
Supplier: Southern Biotechnology


Description: CD45, also known as the leukocyte common antigen (LCA), exists as four different isoforms (180, 190, 205, 220 kDa) that are generated by alternative splicing of three exons. LCA is found on all cells of hematopoietic origin, except erythrocytes and platelets. CD45 expression is required for T cell and B cell antigen receptor-mediated activation.
Catalog Number: 101442-982
Supplier: Southern Biotechnology


Description: Goat Anti-Mouse IgM-AP antibody with minimal reactivity to human proteins for use in ELISA, immunohistochemistry / immunocytochemistry, western blotting, and ELISpot assays.
Catalog Number: 100242-368
Supplier: Southern Biotechnology


Description: Rabbit F(ab')2 Anti-Sheep IgG(H+L)-AP antibody for use in ELISA and immunohistochemistry assays.
Catalog Number: 100244-930
Supplier: Southern Biotechnology


Description: Goat Anti-Human Lambda-AP antibody with minimal reactivity to mouse proteins for use in ELISA assays.
Catalog Number: 103260-022
Supplier: Southern Biotechnology


Description: The monoclonal antibody 2C4 reacts with RLA-DQ-transfected cells, but not with RLA-DR-transfected cells. In normal adult rabbits, the antibody reacts with 30-60% of peripheral blood leukocytes. It has also been reported that the antibody stains lymphocytes and macrophages in the spleen, lymphocytes in the thymic medulla and some cells in the cortex, Kupffer cells in the liver, and synovial lining cells (e.g., infiltrating macrophages) in inflamed synovium. DQα transcripts have been detected in bone marrow and spleen and to a lesser extent in appendix, lymph nodes, and other organs.
Catalog Number: 100244-810
Supplier: Southern Biotechnology


Description: CD19 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed at all stages of B cell differentiation except terminally differentiated plasma cells. It is also present on the cell surface of follicular dendritic cells. CD19 associates with CD21, CD81, Leu 13 and/or MHC Class II molecules to form a signal transduction complex on the B cell surface. This signaling complex modulates the activation threshold for the B cell antigen receptor (BCR).
Catalog Number: 101442-908
Supplier: Southern Biotechnology


Description: Goat Anti-Human IgG-PE antibody for use in flow cytometry and multiplex assays.
Catalog Number: 100244-276
Supplier: Southern Biotechnology


Description: Biotin Anti-Rat IgG1 antibody for use in flow cytometry, ELISA, immunohistochemistry, and ELISpot assays.
Catalog Number: 100244-590
Supplier: Southern Biotechnology


Description: CD57 represents a 110 kDa oligosaccharide antigenic determinant present on a variety of polypeptides, lipids, and chondroitan sulfate proteoglycans. It is expressed on 7-35% of normal peripheral blood lymphocytes, including subsets of NK cells and CD8+ T lymphocytes. The carbohydrate is expressed on various cell adhesion molecules in the nervous system and is suggested to play a role in cell–cell and cell–substrate interactions.
Catalog Number: 103260-216
Supplier: Southern Biotechnology


Description: CD90 (Thy-1) is a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily consisting of a single V-set domain. The Thy-1.2 alloantigen is expressed on all thymocytes, peripheral T lymphocytes, and some intraepithelial T cells of most mouse strains. It is also expressed in the brain and at varying levels on other non-lymphoid tissues. The 30-H12 monoclonal antibody does not cross react with mouse and rat strains bearing the Thy-1.1 alloantigen (e.g., AKR/J, PL).
Catalog Number: 100243-686
Supplier: Southern Biotechnology


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