You Searched For: Cryogenic Vial Closures

Description: PG 99-465 is a high affinity, selective VPAC2 receptor antagonist. It exhibited a 100-fold preference for the VPAC2 over the VPAC1 receptor. The compound showed partial agonistic activity on the VPAC1 receptor and was inactive on the VPAC2 receptor transfected in CHO cells, as well as on naturally expressed human VPAC2 receptors in the SUP T1 cell line. Dickson et al. observed an agonistic effect of PG99-465 on the human VPAC1 and PAC1 receptors. When applied singly, PG99-465 increased [cAMP](i) at all three hVPAC/PAC receptor subtypes.

Catalog Number: H-7292.0500BA

Supplier: Bachem Americas

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Description: Stable isotope-labeled human ghrelin useful for pharmacokinetic/pharmacodynamic studies.

Catalog Number: H-7252.0500BA

Supplier: Bachem Americas

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Description: Please see also α-MSH (corresponds to acetyl-ACTH (1-13) amide, H-1075), α-MSH (free acid) (acetyl-ACTH (1-13), H-1070), and (Des-acetyl)-α-MSH (H-4390). Wied: Pituitary Adrenal System Hormones and Behaviour. Symposium on Developments in Endocrinology (1976) / Anon.: ACTH and Related Peptides: Structure, Regulation, and Action. Ann. N.Y. Acad. Sci. 297, 1 (1977) / A.V.Schally: Aspects of Hypothalamic Regulation of the Pituitary Gland. Science 202, 18 (1978) / R.Schwyzer: Studies on Polypeptide Receptors. A Critical View on the Mechanism of ACTH Action. Bull. Schweiz. Acad. Med. Wiss. 34, 263 (1978).

Catalog Number: H-6754.0001BA

Supplier: Bachem Americas

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Description: Oic derivatives

Catalog Number: F-3105.0250BA

Supplier: Bachem Americas

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Description: Highly efficient coupling additive, a safer, non-explosive alternative to HOBt.

Catalog Number: Q-2750.0025BA

Supplier: Bachem Americas

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Description: Sequence: Fmoc-4-(7-hydroxy-4-coumarinyl)-Abu-OH
Synonym(s): Fmoc-(7-hydroxycoumarin-4-yl)-ethyl-Gly-OH#Fmoc-(umbellifer-4-yl)-ethyl-Gly-OH

Catalog Number: B-4205.1000BA

Supplier: Bachem Americas

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Description: Substitution 0.50-0.90 mmol/g Storage Conditions -20 +/- 5 Deg C 1G

Catalog Number: D-2975.0001BA

Supplier: Bachem Americas

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Description: Bachem also offers phosphothreonine derivatives.

Catalog Number: B-4240.0250BA

Supplier: Bachem Americas

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Description: These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.

Catalog Number: B-4295.0005BA

Supplier: Bachem Americas

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Description: Hepcidin-24 is an excellent alternative to biotinylated or heavy isotope-labeled Hepcidin-25 used as internal reference in the determination of Hep-25 by mass spectrometry-based methods, e.g. in human serum or urine.

Catalog Number: H-7378.1000BA

Supplier: Bachem Americas

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Description: These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.

Catalog Number: B-4310.0005BA

Supplier: Bachem Americas

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Description: Potential impurity of octreotide.

Catalog Number: H-7376.0500BA

Supplier: Bachem Americas

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Description: Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.

Catalog Number: 10796-830

Supplier: Bachem Americas

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Description: SPPS employing the pure stereoisomer of Fmoc-Pam₂Cys-OH allows to obtain more homogeneous lipopeptides. The configuration of the bis-palmitoyloxypropyl moiety could influence the biological activity of the peptide conjugate.

Catalog Number: 10796-864

Supplier: Bachem Americas

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Description: Derivative for the Fmoc-SPPS of backbone-protected peptides. Introduction of Dmb at appropriate positions prevents aggregation and aspartimide formation.Please see also our Dmb-dipeptides.

Catalog Number: B-4170.5000BA

Supplier: Bachem Americas

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Description: Biotinyl-Amylin (human), Trifluoroacetate salt, Molecular Formula: C175H275N53O57S3, Relative Molecular Mass: 4129.63, CAS Registry Number: [1678415-18-3] net, Source: Synthetic, Storage Conditions: -20 +/- 5 degree Celcius, 0.5mg

Catalog Number: 10796-714

Supplier: Bachem Americas

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