You Searched For: OPTEM

Catalog Number: (103259-940)

Supplier: Southern Biotechnology

Description: CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. Although not detectable on resting lymphocytes, its expression is rapidly upregulated upon activation of T, B and NK cells, and neutrophils. Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. The monoclonal antibody H1.2F3 augments PMA-induced T-cell proliferation and induces redirected lysis of Fc receptor-bearing target cells by NK cells.

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Catalog Number: (100242-530)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Mouse IgG(H+L)-PE antibody with minimal reactivity to human proteins for use in flow cytometry assays.

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Catalog Number: (103259-938)

Supplier: Southern Biotechnology

Description: CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. Although not detectable on resting lymphocytes, its expression is rapidly upregulated upon activation of T, B and NK cells, and neutrophils. Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. The monoclonal antibody H1.2F3 augments PMA-induced T-cell proliferation and induces redirected lysis of Fc receptor-bearing target cells by NK cells.

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Supplier: Southern Biotechnology

Description: CD5, a member of the scavenger receptor superfamily of cell surface receptors, is a type I transmembrane glycoprotein whose ligand is CD72. It is expressed on most thymocytes, all mature T cells, and a subset of B cells. CD5 plays a role in regulation of T cell activation and signaling.

Catalog Number: (100246-268)

Supplier: Southern Biotechnology

Description: CD43, a member of the sialomucin family of cell surface receptors, is a 95-135 kDa type I transmembrane glycoprotein whose variability in molecular weight is dependent upon the nature of the extracellular O-glycans. It is the major sialoglycoprotein on thymocytes, T cells, and neutrophils. It is also present on activated B cells, plasma cells, NK cells, granulocytes, monocytes, macrophages, platelets, and bone marrow hematopoietic stem cells. CD43, which binds to ICAM-1 (CD54), appears to function as an anti-adhesion molecule, inhibiting T cell interactions including T cell killing, and by increasing the threshold for T cell activation.

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Catalog Number: (100246-342)

Supplier: Southern Biotechnology

Description: CD57 represents a 110 kDa oligosaccharide antigenic determinant present on a variety of polypeptides, lipids, and chondroitan sulfate proteoglycans. It is expressed on 7-35% of normal peripheral blood lymphocytes, including subsets of NK cells and CD8+ T lymphocytes. The carbohydrate is expressed on various cell adhesion molecules in the nervous system and is suggested to play a role in cell–cell and cell–substrate interactions.

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Catalog Number: (101442-948)

Supplier: Southern Biotechnology

Description: CD10, also known as the common acute lymphoblastic leukemia antigen (CALLA), is a type II transmembrane glycoprotein. It is expressed on granulocytes, a subset of B progenitor cells, germinal center cells, and fibroblasts. CD10 is a zinc-binding metalloprotease which is thought to down-regulate cellular responses to peptide hormones.

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Catalog Number: (100242-088)

Supplier: Southern Biotechnology

Description: Rat IgG2a-PE for use as a control in flow cytometry assays.

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Catalog Number: (100244-562)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Rat IgG-Texas Red antibody with minimal reactivity to mouse proteins for use in flow cytometry and immunohistochemistry assays.

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Supplier: Southern Biotechnology

Description: CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. Although not detectable on resting lymphocytes, its expression is rapidly upregulated upon activation of T, B and NK cells, and neutrophils. Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. The monoclonal antibody H1.2F3 augments PMA-induced T-cell proliferation and induces redirected lysis of Fc receptor-bearing target cells by NK cells.

Catalog Number: (100243-660)

Supplier: Southern Biotechnology

Description: CD86, also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation. CD86, along with CD80 (B7-1), is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152 (CTLA-4). Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. The monoclonal antibody GL1 blocks mixed lymphocyte reactions and stimulation of T cells by antigen-presenting cells.

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Catalog Number: (100245-662)

Supplier: Southern Biotechnology

Description: PE Anti-Human IgM antibody for use in flow cytometry assays.

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Catalog Number: (100242-016)

Supplier: Southern Biotechnology

Description: Purified Goat IgG for use as a control in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and in vitro assays and as a standard in ELISA.

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Catalog Number: (103259-750)

Supplier: Southern Biotechnology

Description: Low Endotoxin/Azide Free Human IgG1 Kappa for use as a control in flow cytometry, immunoprecipitation, Fc mediated stimulation, blocking, and in vivo / in vitro assays, as a standard in ELISA, and for immobilization in surface plasmon resonance.

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Catalog Number: (100242-582)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse Kappa-Texas Red antibody for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (103265-250)

Supplier: Southern Biotechnology

Description: CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin α4 chain. CD49d associates noncovalently with CD29, the integrin β1 subunit, to form the α4β1 very late antigen-4 (VLA-4) heterodimer. Integrin α4 can also associate with integrin β7 to form the α4β7 heterodimer. It is expressed on most leukocytes with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106 (VCAM-1) and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The α4β7 integrin heterodimer is expressed on a small subpopulation of thymocytes, most lymph node T and B lymphocytes, NK cells, and eosinophils. Integrin α4β7 also binds to fibronectin and VCAM-1.

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