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Catalog Number: (100245-386)

Supplier: Southern Biotechnology

Description: Feline CD5, a member of the scavenger receptor family of cell surface receptors, is a type I transmembrane glycoprotein that is expressed on most thymocytes and mature T lymphocytes. CD5 is thought to function in both cell-cell recognition and signal transduction. The monoclonal antibody f43 is useful as a pan T cell marker.

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Catalog Number: (100243-868)

Supplier: Southern Biotechnology

Description: NK1.1, a member of the NKR-P1 family of cell surface receptors, is a type II integral membrane glycoprotein with a C-type lectin domain. It is expressed as a disulfide-linked homodimer on all NK cells as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g., C57BL/6, NZB, and CE). NK1.1 mediates cellular activation and differentiation, and is thought to have a particular role in generating Th2 cells. This product does not react with NK cells of BALB/c mice.

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Catalog Number: (103265-014)

Supplier: Southern Biotechnology

Description: Rabbit Anti-Goat IgG(H+L)-HRP antibody with minimal reactivity to human serum proteins for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (103265-116)

Supplier: Southern Biotechnology

Description: Purified Donkey Anti-Goat IgG Fc antibody for use in ELISA assays.

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Catalog Number: (103264-550)

Supplier: Southern Biotechnology

Description: CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.

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Catalog Number: (100243-838)

Supplier: Southern Biotechnology

Description: The monoclonal antibody YLI-90 reacts with the B6 allele of Ly49I, a member of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells. The YLI-90 antibody stains ~45% of NK1.1+CD3- splenocytes from C57BL/6 mice.

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Catalog Number: (103265-224)

Supplier: Southern Biotechnology

Description: Alexa Fluor 555 Anti-Human IgG4 Fc antibody for use in immunohistochemistry / immunocytochemistry and western blotting assays.

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Catalog Number: (100244-076)

Supplier: Southern Biotechnology

Description: The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity; (ii) the β chain that binds IL-2 with high affinity; and (iii) the common γ chain (γc) that does not bind IL-2. The high affinity receptor complex is an α/β/γ heterotrimer with a Kd of 1.3 x 10-11 M. In mouse spleen, CD122 is expresed on ~30% of CD8+ cells and all NK cells but <1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. The monoclonal antibody 5H4 does not block IL-2 binding.

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Catalog Number: (100242-838)

Supplier: Southern Biotechnology

Description: Purified Anti-Mouse IgA antibody for use in ELISA, flow cytometry, immunohistochemistry, and western blotting assays.

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Catalog Number: (100244-442)

Supplier: Southern Biotechnology

Description: Goat Anti-Rat IgM-TRITC antibody for use in immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (100243-036)

Supplier: Southern Biotechnology

Description: VLA-4 belongs to the β1-integrin family, which functions both as cell-matrix and cell-cell receptors. As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/Pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive. Antibody PS/2 also reacts with human VLA-4.

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Catalog Number: (100242-124)

Supplier: Southern Biotechnology

Description: Rat IgM-PE for use as a control in flow cytometry assays.

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Catalog Number: (100243-722)

Supplier: Southern Biotechnology

Description: Ly-6C is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T-cell subsets. Mice with the Ly-6.2 allotype (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have subsets of CD4+Ly-6C+ and CD8+Ly-6C+ cells while Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have only CD8+Ly-6C+ lymphocytes. Ly-6C may play a role in the development and maturation of lymphocytes.

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Catalog Number: (103259-778)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG2a-Alexa Fluor 647 antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (100242-654)

Supplier: Southern Biotechnology

Description: Purified Goat F(ab’)2 Anti-Mouse IgG1 antibody with minimal reactivity to human proteins for use in ELISA, flow cytometry, and immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (103265-560)

Supplier: Southern Biotechnology

Description: FITC Anti-Mouse Foxp3 antibody for use in flow cytometry and immunohistochemistry assays.

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