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Supplier: Biotium

Description: The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

Supplier: Biotium

Description: Complement C4d Monoclonal antibody, Clone: TDM16, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Human Complement 4d protein, Application: Immunofluorescence, Flow cytometry, Size: 500 uL

Supplier: Biotium

Description: Complement C4d Monoclonal antibody, Clone: C4D205, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: biotin, Immunogen: Recombinant human Complement 4d protein, Application: ImmunoFluorescence, Size: 500 uL

Supplier: Biotium

Description: Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Description: This antibody recognizes a protein of 40 kDa, identified as cytokeratin-19 (CK19), which is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Description: Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Keratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract. Antibody to cytokeratin is useful in distinguishing ovarian carcinomas (keratin 7 ) from colon carcinomas (keratin 7-).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

Description: This antibody recognizes a transcription factor of 64-67 kDa, identified as c-myc. This MAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or over-expressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease. Rearrangement of the MYC gene is found in 3% to 16% of diffuse large B-cell lymphoma (DLBCL's) and in nearly 100% of Burkitt lymphomas (BL). Identifying MYC status is important in establishing final diagnosis of DLBCL, BL, or B-cell lymphoma, with features intermediate between DLBCL and BL as well as in differential diagnoses of the lymphomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: This MAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.

Supplier: Biotium

Description: Llama anti-rabbit CF™ dye conjugates are prepared by labeling affinity purified llama anti-rabbit IgG (H+L) with a selection of CF™ dyes. CF™ dyes offer combined advantages in brightness, photostability, and specificity compared other fluorescent dyes. Red fluorescent CF™568 (Ex/Em 562/583 nm) produces much brighter antibody conjugates than Alexa Fluor® 568, and has superior photostability.

Alexa Fluor® is a registered trademark of Thermo Fisher Scientific.

Supplier: Biotium

Description: Llama anti-rabbit CF™ dye conjugates are prepared by labeling affinity purified llama anti-rabbit IgG (H+L) with a selection of CF™ dyes. CF™ dyes offer combined advantages in brightness, photostability, and specificity compared other fluorescent dyes. CF™640R (Ex/Em 642/662 nm) is a novel far-red rhodamine-based dye spectrally similar to Cy®5 and Alexa Fluor® 647. CF™640R is much brighter than Cy®5 and at least as bright as Alexa Fluor® 647 when excited at 633 or 635 nm. However, the most important advantage of CF™640R is its exceptional photostability.

Alexa Fluor® is a registered trademark of Thermo Fisher Scientific. Cy®5 is a registered trademark of GE Healthcare.

Supplier: Biotium

Description: Goat anti-human IgG, Fc gamma specific antibody reacts specifically with the human IgG heavy (γ) chains and not with light chains and F(ab’)2 fragment on all human immunoglobulins. To minimize cross-reactivity, it has been adsorbed against bovine, horse, mouse and rabbit serum proteins prior to conjugation. CF™594 (Ex/Em 593/614 nm) is a deep-red dye spectrally similar to Alexa Fluor® 594 and Texas Red® dye but yields much brighter protein conjugates due to its high quantum yield and exceptional water solubility. CF™594 also has excellent photostability ideal for demanding applications, such as confocal microscopy and single molecule imaging.

Alexa Fluor® and Texas Red® are registered trademarks of Thermo Fisher Scientific.

Catalog Number: (10001-956)

Supplier: Biotium

Description: Llama anti-mouse CF™ dye conjugates are prepared by labeling affinity purified llama anti-mouse IgG (H+L) with a selection of CF™ dyes. CF™ dyes offer combined advantages in brightness, photostability, and specificity compared other fluorescent dyes. CF™594 (Ex/Em 593/614 nm) is a deep-red dye spectrally similar to Alexa Fluor® 594 and Texas Red® dye but yields much brighter protein conjugates due to its high quantum yield and exceptional water solubility. CF™594 also has excellent photostability ideal for demanding applications, such as confocal microscopy and single molecule imaging.

Alexa Fluor® and Texas Red® are registered trademarks of Thermo Fisher Scientific.

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Catalog Number: (10001-886)

Supplier: Biotium

Description: Goat anti-human IgG, Fc gamma specific antibody reacts specifically with the human IgG heavy (γ) chains and not with light chains and F(ab’)2 fragment on all human immunoglobulins. To minimize cross-reactivity, it has been adsorbed against bovine, horse, mouse and rabbit serum proteins prior to conjugation. CF™594 (Ex/Em 593/614 nm) is a deep-red dye spectrally similar to Alexa Fluor® 594 and Texas Red® dye but yields much brighter protein conjugates due to its high quantum yield and exceptional water solubility. CF™594 also has excellent photostability ideal for demanding applications, such as confocal microscopy and single molecule imaging.

Alexa Fluor® and Texas Red® are registered trademarks of Thermo Fisher Scientific.

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Supplier: Biotium

Description: Llama anti-mouse CF™ dye conjugates are prepared by labeling affinity purified llama anti-mouse IgG (H+L) with a selection of CF™ dyes. CF™ dyes offer combined advantages in brightness, photostability, and specificity compared other fluorescent dyes. CF™594 (Ex/Em 593/614 nm) is a deep-red dye spectrally similar to Alexa Fluor® 594 and Texas Red® dye but yields much brighter protein conjugates due to its high quantum yield and exceptional water solubility. CF™594 also has excellent photostability ideal for demanding applications, such as confocal microscopy and single molecule imaging.

Alexa Fluor® and Texas Red® are registered trademarks of Thermo Fisher Scientific.

Catalog Number: (10001-962)

Supplier: Biotium

Description: Llama anti-mouse CF™ dye conjugates are prepared by labeling affinity purified llama anti-mouse IgG (H+L) with a selection of CF™ dyes. CF™ dyes offer combined advantages in brightness, photostability, and specificity compared other fluorescent dyes. CF™640R (Ex/Em 642/662 nm) is a novel far-red rhodamine-based dye spectrally similar to Cy®5 and Alexa Fluor® 647. CF™640R is much brighter than Cy®5 and at least as bright as Alexa Fluor® 647 when excited at 633 or 635 nm. However, the most important advantage of CF™640R is its exceptional photostability.

Alexa Fluor® is a registered trademark of Thermo Fisher Scientific. Cy®5 is a registered trademark of GE Healthcare.

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Supplier: Biotium

Description: This conjugate is prepared by labeling F(ab’)2 fragment of goat anti-rabbit IgG (H+L) with CF™594 dye. CF™ dyes offer advantages in brightness, photostability, and specificity compared to other fluorescent dyes. Deep-red fluorescent CF™594 (Ex/Em 593/614 nm) is spectrally similar to Alexa Fluor® 594 and Texas Red® dye but yields much brighter protein conjugate, and has excellent photostability.

Alexa Fluor® and Texas Red® are registered trademarks of Thermo Fisher Scientific.