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Description: MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF, D5, recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.

Catalog Number: 75961-396

Supplier: Biotium

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Description: CD31 / PECAM-1 Monoclonal antibody, Clone: C31.3 + C31.7 + C31.10, Host: Mouse, Species reactivity: Rabbit, Cynomolgus monkey, Rat, Human, Isotype: IgG1, K, Conjugate: BSA-free, Immunogen: Human Recom CD31, Synonyms: EndoCAM, Application: IF, Size: 50 uL

Catalog Number: 75892-654

Supplier: Biotium

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Description: Progesterone, Monoclonal antibody, Clone: 6-5E-3F, Host: Mouse, Species reactivity: All species, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Progesterone hemisuccinate conjugated to BSA, Synonyms: Pregn 4 ene 3 20 dione, Application: RIA, Size: 100uL

Catalog Number: 75970-286

Supplier: Biotium

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Description: Hepatocyte Specific, Monoclonal antibody, Clone: OCH1E5, Host: Mouse, Species reactivity: Human, Dog, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Recombinant human CPS1 protein, Synonyms: Carbamoylphosphate synthetase 1, Size: 500uL

Catalog Number: 75951-214

Supplier: Biotium

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Description: This MAb is specific to c-erbB-2/HER-2 and shows minimal cross-reaction with other members of the family. C-erbB-2/HER-2 is a member of the EGFR family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75952-634

Supplier: Biotium

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Description: is prepared by labeling IgG with CF568, a red fluorescent dye with an excitation spectrum optimal for the 568 nm laser line. Antibody conjugates of the dye are brighter & more photostable than those of Alexa Fluor 568, making CF568 a better choice for demanding applications.

Catalog Number: 89138-580

Supplier: Biotium

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Description: This MAb recognizes granulocyte-colony stimulating factor (G-CSF) in the cytoplasm of mature granulocytes. It shows no reactivity with any other cell types. Markers of myeloid cells are useful in the identification of different levels of cellular differentiation. It reacts with early precursor and mature forms of myeloid cells. It is useful for the detection of myeloid leukemias and granulocytic sarcomas. It can be used as a marker of granulocytes in normal tissues or inflammatory processes.G-CSF is a pleiotropic cytokine that influences differentiation, proliferation and activation of the neutrophilic granulocyte lineage. The human G-CSF cDNA encodes a 207 amino acid precursor containing a 29 amino acid signal peptide that is proteolytically cleaved to form a 178 amino acid residue mature protein. Two G-CSF's, which are identical except for a three amino acid deletion in the amino-terminus of one form of the protein have been isolated from human cells. Murine and human G-CSF's share 73% sequence identity at the amino acid level.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75927-352

Supplier: Biotium

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Description: The mouse monoclonal antibody recognizes CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.

Catalog Number: 75890-040

Supplier: Biotium

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Description: A qPCR master mix containing Evagreen® qPCR dye and Cheetah™ Taq hotstart DNA polymerase, suitable for qPCR using a fast cycling protocol.

Catalog Number: 89410-662

Supplier: Biotium

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Description: PAX7, Monoclonal antibody, Clone: PAX7/1187, Host: Mouse, Species reactivity: Mouse, Zebrafish, Rat, Human, Chicken, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant fragment (aa300-600) of human PAX7 protein, Synonyms: Paired box gene 7, Size: 100uL

Catalog Number: 75969-334

Supplier: Biotium

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Description: PLAP (Placental Alkaline Phosphatase), Monoclonal antibody, Clone: ALP/870, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF488A, Immunogen: Recombinant full-length human ALPP protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL

Catalog Number: 75970-234

Supplier: Biotium

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Description: Calponin-1 Monoclonal antibody, Clone: CALP, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG's, Conjugate: purified, Immunogen: Crude human uterus extract, Synonyms: CNN1, Cnn1, Application: IF, IHC, FC, Size: 500 uL

Catalog Number: 75882-894

Supplier: Biotium

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Description: c-MyB Monoclonal antibody, Clone: MYB286, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: A synthetic peptide, corresponding to aa 119-135, Synonyms: c-myb_CDS, efg, ONCOGENE AMV, Application: IF, FC, Size: 100uL

Catalog Number: 75920-972

Supplier: Biotium

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Description: This antibody recognizes a 67 kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma ( ) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75914-072

Supplier: Biotium

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Description: PLAP (Placental Alkaline Phosphatase), Monoclonal antibody, Clone: ALPP/238, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF647, Immunogen: Recombinant full-length human ALPP protein, Application: IF, Immunohistology (formalin), Flow, Size: 500uL

Catalog Number: 75970-380

Supplier: Biotium

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Description: This antibody recognizes a protein of 110 kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.

Catalog Number: 75881-756

Supplier: Biotium

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