You Searched For: Cryopreservation

Description: Neurofilament (H+L), Monoclonal antibody, Clone: NF421 + NFL736, Host: Mouse, Species reactivity: Pig, Rat, Human, Chicken, Isotype: IgG's, BSA-free, Immunogen: Recombinant human neurofilament heavy sub-unit (RT-97) & light sub-unit (NR-4), Size: 50 uL

Catalog Number: 75965-800

Supplier: Biotium

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Description: This antibody recognizes a phosphor-protein of 45 kDa, identified as MyoD1. This MAb does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Catalog Number: 75964-822

Supplier: Biotium

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Description: Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.

Catalog Number: 75981-418

Supplier: Biotium

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Description: beta-2 microglobulin Monoclonal antibody, Clone: BBM.1, Host: Mouse, Species reactivity: Human, Non-human primates, Isotype: IgG2b, K, Conjugate: BSA-free, Immunogen: MOLT-4 human T cell line, Synonyms: B2M, Application: IF, Size: 50 uL

Catalog Number: 75882-154

Supplier: Biotium

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Description: Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.

Catalog Number: 75920-540

Supplier: Biotium

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Description: This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.

Catalog Number: 75953-976

Supplier: Biotium

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Description: Glycophorin A / CD235A, Monoclonal antibody, Clone: GYPA/280, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF488A, Immunogen: Human erythrocytes treated with neuraminidase, Synonyms: Blood group-MN locus; GPA; GPErik; GPSAT, Size: 100uL

Catalog Number: 75949-780

Supplier: Biotium

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Description: S100A9, Monoclonal antibody, Clone: 47-8D3, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgM, Conjugate: CF405S, Immunogen: Human peripheral blood monocyte components, Application: Immunofluorescence, Immunohistology (formalin), Flow cytometry, Size: 500uL

Catalog Number: 75973-804

Supplier: Biotium

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Description: This MAb reacts with a 200 kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L), 160 kDa (NF-M) and 200 kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

Catalog Number: 75965-648

Supplier: Biotium

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Description: Glypican-3 Monoclonal antibody, Clone: 1G12, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: A Recom fragment containing amino acids 511-580, Synonyms: DGSX, GPC3, GTR2-2, Application: IF, IHC, Size: 100uL

Catalog Number: 75926-942

Supplier: Biotium

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Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Catalog Number: 75909-914

Supplier: Biotium

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Description: Anti-IgG Goat Polyclonal Antibody (CF™ 488A)

Catalog Number: 89493-074

Supplier: Biotium

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Description: Cytokeratin, LMW Monoclonal antibody, Clone: AE-1, Host: Mouse, Species reactivity: Mouse, Turtle, Monkey, Dog, Cow, Rat, Human, Chicken, Rabbit, Isotype: IgG1, K, Conjugate: CF488A, Immunogen: Human epidermal keratin, Synonyms: K1B, Size: 500 uL

Catalog Number: 75916-916

Supplier: Biotium

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Description: Biotin-AM3-25 is a conjugate of AM3-25 and biotin. Membranes labeled with the probe can subsequently couple to avidin or streptavidin.

Catalog Number: 89139-338

Supplier: Biotium

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Description: Actinomycin D is a nonfluorescent GC-selective intercalator.

Catalog Number: 10018-186

Supplier: Biotium

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Description: Von Willebrand Factor, Monoclonal antibody, Clone: 3E2D10, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human vWF fragment spanning aa 845-949, Synonyms: Coagulation Factor VIII, Application: IF, Size: 100uL

Catalog Number: 75978-942

Supplier: Biotium

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