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Supplier: Biotium

Description: Pmel17 / gp100 / SILV, Monoclonal antibody, Clone: NKI-beteb, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Extract of pigmented melanoma metastases from lymph nodes, Application: Immunofluorescence, Flow, Size: 500uL

Supplier: Biotium

Description: Nucleolar / NucleolI, Monoclonal antibody, Clone: NM95, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Nuclei of myeloid leukemia biopsy cells, Application: Immunofluorescence, Immunohistology (formalin), Size: 100uL

Catalog Number: (75907-978)

Supplier: Biotium

Description: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

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Catalog Number: (75910-314)

Supplier: Biotium

Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

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Catalog Number: (89493-286)

Supplier: Biotium

Description: Anti-IgG Goat Antibody (CF™ 594)

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Supplier: Biotium

Description: Fibronectin Monoclonal antibody, Clone: 2755-8, Host: Mouse, Species reactivity: Mouse, Pig, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: T-cell lymphoma biopsy, Synonyms: FN1, FNZ, GFND, GFND2, Application: IF, IHC, Size: 500 uL

Supplier: Biotium

Description: Golgi Complex, Monoclonal antibody, Clone: AE-6, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: SU-DHL-1 large cell lymphoma cells, Synonyms: Golgi Complex; Golgi apparatus; Golgi zone, Size: 500uL

Catalog Number: (75961-044)

Supplier: Biotium

Description: MHC II (HLA-DP), Monoclonal antibody, Clone: BRA-FB6, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, BSA-free, Immunogen: Human REH cells, Application: Immunofluorescence, Immunohistology (formalin), Flow cytometry, Size: 50 uL

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Supplier: Biotium

Description: The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Keratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract. Antibody to cytokeratin is useful in distinguishing ovarian carcinomas (keratin 7 ) from colon carcinomas (keratin 7-).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: (75914-450)

Supplier: Biotium

Description: This antibody recognizes a protein of 33-55 kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.

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Supplier: Biotium

Description: Cytokeratin 10 Monoclonal antibody, Clone: KRT10/844, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recom human KRT10 protein, Synonyms: BCIE, BIE, EHK, Application: IF, IHC, FC, Size: 100uL

Supplier: Biotium

Description: Lung Specific Antigen, Monoclonal antibody, Clone: LSA120, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Protein extract of human lung cells, Application: Immunofluorescence, Size: 500uL

Supplier: Biotium

Description: This antibody recognizes the blood group H type 2 antigens, trisaccharide Fuca1-2Galb1-4GlcNAc of human origin. This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. It is expressed on endothelial cells, epithelial cells and granulocytes. Increased expression of this antigen has been observed on some tumor tissues such as gastric carcinomas, urothelial carcinomas, and colon carcinomas.

Supplier: Biotium

Description: CD79A Monoclonal antibody, Clone: IGA/764, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant human IGA protein, Application: IF, Immunohistology (formalin), FC, Size: 100uL

Supplier: Biotium

Description: CD37 Monoclonal antibody, Clone: IPO-24, Host: Mouse, Conjugate: CF640R, Species reactivity: Human, Immunogen: Spleen cells of a patient with hairy cell leukemia, Isotype: IgG2b, kappa, Synonyms:Cell differentiation antigen 37, Application: IF, FC, Size: 100uL