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Catalog Number: (89427-198)

Supplier: Biotium

Description: Antibody Conjugates Prepared From Near-Infrared Cf790 Dye Are Brighter And Have The Best Signal-To-Noise Ratio Compared To Spectrally Similar Dyes; Antibody Has Minimal Cross-Reactivity With Human, Bovine, Horse, Rabbit And Swine Serum Proteins

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Supplier: Biotium

Description: beta-2-microglobulin Monoclonal antibody, Clone: B2M/1118, Host: Mouse, Species: Human, Non-human primates, Isotype: IgG2b, kappa, Conjugate: CF647, Immunogen: 12KDa protein with a pI of 5.6. Serum B2 microglobulin, Synonyms: B2M, Beta 2 microglobin, Size: 100ul

Supplier: Biotium

Description: Cytokeratin 18 Monoclonal antibody, Clone: DC10, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: CF568, Immunogen: PMC-42 human breast carcinoma cells, Synonyms: K18, Application: IF, IHC, WB, FC, Size: 100uL

Supplier: Biotium

Description: MHC I, Monoclonal antibody, Clone: 108-2C5, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Normal human peripheral blood lymphocytes, Synonyms: HLA-A; HLA class 1A; MHC class I HLA-A, Application: Immunofluorescence, Flow, Size: 500uL

Supplier: Biotium

Description: Lumitein™ is a luminescent dye designed for detecting proteins in SDS polyacrylamide (SDS-PAGE) gels. It can also be used to detect proteins in native PAGE gels after an additional SDS incubation step. The stain combines excellent sensitivity, exceptional user-friendliness and compatibility with common instruments and downstream analysis.

Supplier: Biotium

Description: PAb122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Supplier: Biotium

Description: Human Nuclear Antigen, Monoclonal antibody, Clone: 235-1, Host: Mouse, Species reactivity: Human, Non-human primates, Isotype: IgG1, kappa, Conjugate: CF543, Immunogen: Nuclei of human myeloid leukemia biopsy cells, Synonyms: HNA; HuNu, Application: IF, Size: 100uL

Supplier: Biotium

Description: This antibody reacts with five invariable CD3 chains designated CD3y, CD3d, CD3e, CD3f, and CD3n with molecular weight ranging from 16-28 kDa. It is found on all mature T-lymphocytes, NK, T-cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. It is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly intracytoplasmic. This MAb is particularly useful for induction of T cell activation in vitro and in vivo due to its unusual IgG3 isotype.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®680R is a near-infrared fluorescent dye (Ex/Em 680/701 nm) with unrivaled photostability. It also is validated in super-resolution imaging by STED and single-molecule spectroscopy.

Supplier: Biotium

Description: CD10 Monoclonal antibody, Clone: CB-CALLA, Host: Mouse, Reactivity: Human, Isotype: IgG2b, kappa (confirmed and correct), Conjugate: CF640R, Immunogen: Recognizes a 100kDa glycoprotein, CD10, also known as CALLA, Applications: Immunofluorescence, Flow cytometry, Size: 100ul

Supplier: Biotium

Description: CD27 Monoclonal antibody, Clone: 203.6, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: biotin, Immunogen: Sezary cells, Synonyms: T14, TNFRSF7, TNFSF7, Tp55, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

Description: This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

Description: Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.

Supplier: Biotium

Description: PTH / Parathyroid Hormone (N-Terminal), Monoclonal antibody, Clone: PTH/1174, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: biotin, Immunogen: synthetic peptide from N-terminal of PTH polypeptide, Synonyms: Parathyrin, Size: 500uL

Supplier: Biotium

Description: MHC II (HLA-DQ), Monoclonal antibody, Clone: SPV-L3, Host: Mouse, Species reactivity: Human, Pig, Isotype: IgG2a, kappa, Conjugate: purified, Immunogen: T4-positive CTL clone HG-38, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Description: TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3 + CC49, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 100uL