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Catalog Number: (89138-848)

Supplier: Biotium

Description: Ponceau S staining solution is used for the detection of proteins on PVDF and nitrocellulose membranes with a limit of detection of about 250 ng of transferred protein.

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Supplier: Biotium

Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

Description: A qPCR master mix containing Evagreen® qPCR dye and Cheetah™ Taq hotstart DNA polymerase, suitable for qPCR using a fast cycling protocol.

Supplier: Biotium

Description: CD74 Monoclonal antibody, Clone: CLIP/1133, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Recombinant full-length human CD74 protein, Application: IF, Western, FC, Size: 500 uL

Supplier: Biotium

Description: Lambda Light Chain, Monoclonal antibody, Clone: HP6054, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF647, Immunogen: Purified IgG myeloma proteins coupled to polyaminostyren, Synonyms: BJP, Application: IF, Size: 100uL

Supplier: Biotium

Description: This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Description: This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81 kDa) and PR-B (116 kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone.

Supplier: Biotium

Description: This product is prepared by labeling F(ab’)2 fragment of goat anti-mouse IgG (H+L) with Allophycocyanin (APC). APC belongs to the family of phycobiliproteins, which are derived from cyanobacteria and eukaryotic algae. APC has absorption maxima at 650 and emission at 660 nm. Because of the high fluorescence quantum yield (~0.68), APC is by far the brightest dye for the 650 nm wavelength region.

SDS

Supplier: Biotium

Description: This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.It stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).

Catalog Number: (89493-174)

Supplier: Biotium

Description: Anti-IgG Rabbit Antibody (CF™ 568)

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Supplier: Biotium

Description: MART-1 / Melan-A, Monoclonal antibody, Clone: M2-7C10, Host: Mouse, Species reactivity: Mouse, Dog, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Recombinant hMART-1 protein, Synonyms: Antigen LB39-AA, Application: IF, IHC Western, Size: 100uL

Supplier: Biotium

Description: Eosinophil Peroxidase Monoclonal antibody, Clone: EPO104, Host: Mouse, Species reactivity: Human, Isotype: IgG1, K, Conjugate: CF647, Immunogen: Human eosinophils, hypereosinophilic syndrome, Synonyms: EPER, Application: IF, Size: 500 uL

Supplier: Biotium

Description: CD50 Monoclonal antibody, Clone: 101-1D2, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF488A, Immunogen: Stimulated human leukocytes, Synonyms: ICAMR, Intercellular adhesion molecule 3, Application: IF, Immunohistology, Size: 500 uL

Supplier: Biotium

Description: CD16 Monoclonal antibody, Clone: ICO-116, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF594, Immunogen: Human CD16 proteinUnigene 372679, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Catalog Number: (75892-426)

Supplier: Biotium

Description: CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

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Supplier: Biotium

Description: This antibody recognizes a protein doublet of 20-22 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.