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Description: This antibody recognizes a myeloid associated differentiation antigen in the cytoplasm of mature granulocytes. It shows no reactivity with any other cell type in human tissues. Markers of myeloid cells are useful in the identification of different levels of cellular differentiation. It reacts with early precursor and mature forms of human and monkey myeloid cells. This MAb is useful for the detection of myeloid leukemias and granulocytic sarcomas. It can be used as a marker of granulocytes in normal tissues or inflammatory processes.

Catalog Number: 75968-340

Supplier: Biotium

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Description: This antibody recognizes a cell surface glycoprotein of 80-95 kDa (CD44) on lymphocytes, monocytes, and granulocytes (Leucocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44 immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®555 is a bright orange-red fluorescent dye (Ex/Em 555/565 nm) that is compatible with super-resolution imaging by STORM.

Catalog Number: 75912-698

Supplier: Biotium

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Description: Myosin, Smooth Muscle Heavy Chain, Monoclonal antibody, Clone: MYH11/923 + SMMS-1, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG's, Conjugate: CF405S, Immunogen: Recombinant human MYH11 protein, Synonyms: AAT4, Application: IF, Size: 500uL

Catalog Number: 75965-088

Supplier: Biotium

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Description: Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75916-288

Supplier: Biotium

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Description: Von Willebrand Factor, Monoclonal antibody, Clone: 3E2D10 + VWF635, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human vWF fragment spanning aa 845-949, Synonyms: Coagulation Factor VIII, Size: 100uL

Catalog Number: 75979-130

Supplier: Biotium

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Description: This antibody recognizes a phosphor-protein of 45 kDa, identified as MyoD1. This MAb does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75964-816

Supplier: Biotium

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Description: Biocytin (ε-Biotinoyl-L-lysine) is a cellular tracer that can be introduced into cells by microinjection.

Catalog Number: 89139-610

Supplier: Biotium

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Description: Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as an epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75916-352

Supplier: Biotium

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Description: HSP60, Monoclonal antibody, Clone: GROEL/730, Host: Mouse, Species reactivity: Mouse, Hamster, Monkey, Pig, Dog, Cow, Sheep, Rat, Human, Chicken, Rabbit, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant human HSPD1 protein, Application: IF, Size: 500uL

Catalog Number: 75953-398

Supplier: Biotium

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Description: The epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Catalog Number: 75972-848

Supplier: Biotium

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Description: Lambda Light Chain, Monoclonal antibody, Clone: LcN-2 + ICO-106, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF405S, Immunogen: IgG myeloma proteins coupled to polyaminostyren microbeads, Synonyms: BJP, Size: 100uL

Catalog Number: 75956-410

Supplier: Biotium

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Description: GnRH-Receptor (LHRH Receptor), Monoclonal antibody, Clone: F1G4, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: A synthetic peptide aa 1-29 from the N-terminal of human GnRH receptor, Application: IF, Flow, Size: 500uL

Catalog Number: 75948-746

Supplier: Biotium

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Description: Min X Bv Ch Ft GP Hs Hu Rb Rt Sh SHm. CF594 antibodies are labeled with deep red CF594 dye which is spectrally similar to Alexa Fluor 594.

Catalog Number: 89411-486

Supplier: Biotium

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Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75910-268

Supplier: Biotium

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Description: Cyclin A2 Monoclonal antibody, Clone: E67, Host: Mouse, Species reactivity: Mouse, Mink, Green monkey, Monkey, Cow, Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Full length bovine Cyclin A, Synonyms: CCN1, CCNA, CCNA2, Application: IF, Size: 100uL

Catalog Number: 75923-104

Supplier: Biotium

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Description: HCG-beta, Monoclonal antibody, Clone: HCGb/54+ HCGb/459, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF488A, Immunogen: Recombinant hCG beta protein (HCGb/54 and HCGb/459), Synonyms: CG-beta; CGB3; CGB5; CGB7; CGB8, Application: IHC, Size: 100uL

Catalog Number: 75951-810

Supplier: Biotium

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