You Searched For: VIKAN NORTH AMERICA CORPORATION

Catalog Number: (77007-560)

Supplier: Genscript

Description: Secukinumab with brand name Cosentyx, is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is marketed by Novartis for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Secukinumab inhibits a member of the cytokine family, interleukin 17A, which is produced mainly by inflammatory T helper 17 cells. IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and promotes inflammation when it binds to the interleukin-17 receptor. Anti-Secukinumab Antibody (23E11), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Secukinumab.

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Catalog Number: (77007-614)

Supplier: Genscript

Description: Panitumumab with trade name Vectibix, is an FDA-approved drug for the treatment of patients with EGFR-expressing metastatic colorectal carcinoma with non-mutated (wild-type) KRAS after failure of fluoropyrimidine-, oxaliplatin- and irinotecan-containing chemotherapy regimens. It is a human monoclonal antibody. Panitumumab binds to the human EGF receptor (EGFR), preventing binding of activating ligands, such as the EGF and transforming growth factor alpha. GenScript anti-panitumumab antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Panitumumab.

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Catalog Number: (89493-644)

Supplier: Genscript

Description: THE™ DYKDDDDK Tag antibody [Biotin], mAb, Mouse recognizes C-terminal, N-terminal and internal tagged fusion proteins.

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Catalog Number: (89495-084)

Supplier: Genscript

Description: GenScript THE™ HA Tag antibody [FITC], mAb, Mouse recognizes C-terminal, N-terminal and internal HA tagged fusion proteins.

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Catalog Number: (89495-086)

Supplier: Genscript

Description: GenScript THE™ His Tag antibody [FITC], mAb, Mouserecognizes C-terminal, N-terminal and internal His tagged fusion proteins.

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Catalog Number: (89495-088)

Supplier: Genscript

Description: THE™ His Tag antibody [HRP], mAb, Mouse recognizes His tags localized at C-terminal, N-terminal and internal region of fusion proteins

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Supplier: Genscript

Description: SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease in 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. Lineage B.1.351 (a.k.a. 20H/501Y.V2) is a variant of SARS-CoV-2. It has multiple mutations in the RBD, including K417N, E484K, N501Y. Lineage B.1.1.7 (a.k.a. 20I/501Y.V1) is also a variant of SARS-CoV-2 and has a mutation called N501Y in the RBD.SARS-CoV-2 Spike (N501) neutralizing antibody (COV2110) is produced from cell culture <i>in vitro</i> under conditions free from animal-derived components. The product is a humanized neutralizing antibody, recognizing N501 site of wild-type RBD. When N501 is mutated to N501Y, the mutant RBD, such as RBD (B.1.1.7) and RBD (B.1.351) as seen in Figure 1, can't be recognized by the product.

Catalog Number: (77007-650)

Supplier: Genscript

Description: Payloads are the important components of antibody-drug conjugates (ADCs). The most commonly used ADC payloads are MMAE, DM1, and DXd. ADC pharmacokinetic (PK) studies include free payload analysis, conjugated antibody analysis, and total antibody analysis via ligand-binding assay (LBA) and LC-MS/MS assay. The anti-payload antibody is a useful reagent in PK assay for determining conjugated antibodies. It can be used as a capture antibody to determine the conjugated antibody in LBA assay or through immunocapture to enrich the ADC sample in LC-MS/MS assay. The DXd, also known as exatecan derivative, is a potent inhibitor of DNA topoisomerase I. Trastuzumab deruxtecan (T-DXd, DS-8201a or Enhertu®), composed of trastuzumab conjugated to DXd, is the first approved ADC for the treatment of breast cancer.

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Catalog Number: (76509-966)

Supplier: Genscript

Description: The product is specific for Rituximab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01970-40, Anti-Rituximab Antibody (17B6), mAb, Mouse.

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Catalog Number: (10498-192)

Supplier: Genscript

Description: THE™ V5 tag antibody [iFluor 647], mAb, mouse recognizes N-terminal, internal and C-terminal V5-tagged proteins.

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Catalog Number: (77007-528)

Supplier: Genscript

Description: Golimumab with trade name Simponi, is an FDA-approved drug for the treatment of Rheumatoid arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS) and Ulcerative Colitis (UC). It is a human IgG1κ monoclonal antibody that binds to Tumor Necrosis Factor alpha (TNF-alpha), thereby inhibiting the binding to TNF alpha receptors and subsequent generation of inflammatory cytokines. GenScript Anti-Golimumab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Golimumab.

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Catalog Number: (77007-526)

Supplier: Genscript

Description: A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

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Catalog Number: (77007-608)

Supplier: Genscript

Description: Human IgG is the major immunoglobulin in blood and plays a key role in the humoral immune response. The Fc portion of human IgG binds to Fc receptor that can activate the complement system. Fc-tagged proteins are generated with DNA recombinant technology. The protein of interest is fused with the Fc tag. Most vectors encoding for Fc tag sequence use the Fc region of human IgG1. Protein A can be used for the purification of Fc-tagged proteins. Human IgG (Fc), mAb, Mouse is a useful tool for immunoassay of human Fc-tagged proteins and human IgG.GenScript Human IgG (Fc) Antibody, mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with human Fc-tagged protein.

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Catalog Number: (77007-604)

Supplier: Genscript

Description: Dupilumab with trade name Dupixent, is an FDA-approved drug for the treatment of patients aged 6 years and older with moderate-to-severe atopic dermatitis. It is a human monoclonal antibody. Dupilumab binds to the interleukin-4 receptor alpha (IL-4R alpha) subunit shared by the interleukin (IL)-4 and IL-13 receptor complexes, thereby inhibiting IL-4 and IL-13 signaling. Anti-Dupilumab Antibody (2D5), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Dupilumab.

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Supplier: Genscript

Description: GenScript’s THE™ PEG Antibody, mAb, Mouse has high affinity for the PEG backbone. The antibody binds to the variety of PEG such as PEG40K, PEG20K, PEG5K, PEG12, PEGylated drugs and PEG conjugates. and nbsp.

Catalog Number: (76509-988)

Supplier: Genscript

Description: The product is specific for human TIGIT.

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