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Supplier: Enzo Life Sciences
Description: Recommended Applications: ELISA, IHC, IP, WB

Species reactivity: Human, Hamster, Cat

Supplier: Enzo Life Sciences
Description: The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsd70 cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.

SDS

Supplier: Enzo Life Sciences
Description: Acetyl-CoA inhibitor

Catalog Number: (89146-830)
Supplier: Enzo Life Sciences
Description: Caspase inhibitor


Catalog Number: (89165-828)
Supplier: Enzo Life Sciences
Description: Bio-16-dUTP (Biotin-16-2’-deoxyuridine-5’-triphosphate) can replace TTP in reactions in which it serves as a substrate for E. coli DNA polymerase (holoenzyme and Klenow fragment), T4 and Taq DNA polymerases, reverse transcriptase (from AMV and M-MuLV) and terminal transferase.


Supplier: Enzo Life Sciences
Description: Reduces blood calcium

Catalog Number: (89147-972)
Supplier: Enzo Life Sciences
Description: Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ).


Catalog Number: (89141-246)
Supplier: Enzo Life Sciences
Description: COMET SCGE Assay measures DNA damage by fluorescently detecting the integrity of DNA liberated from cells embedded in low melting point agarose. Upon electrophoresis, fragmented DNA produces a characteristic "comet" shaped tail as small DNA fragments migrate in the gel more rapidly than in-tact genomic DNA.

SDS


Catalog Number: (89155-222)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Catalog Number: (89157-004)
Supplier: Enzo Life Sciences
Description: PKA activator.


Supplier: Enzo Life Sciences

Supplier: Enzo Life Sciences

Catalog Number: (89147-736)
Supplier: Enzo Life Sciences
Description: Highly selective and potent inhibitor of cyclooxygenase-2 (IC50=10nM for COX-2 versus IC50=17.8µM for COX-1) with antitumor properties. Exhibits longer half-life time and reduced gastric toxicity in fasting rat model. Has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. Potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.


Supplier: Enzo Life Sciences
Description: PARP-1 inhibitor

Catalog Number: (89156-764)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Catalog Number: (89153-118)
Supplier: Enzo Life Sciences
Description: TLR9 inhibitor


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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