You Searched For: Antibodies

Catalog Number: (75929-234)

Supplier: Rockland Immunochemical

Description: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Catalog Number: (RL618-102-130)

Supplier: Rockland Immunochemical

Description: Secondary Goat Anti-IgG IgA IgM Reacts with Ferret

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Catalog Number: (RL200-301-G42)

Supplier: Rockland Immunochemical

Description: Anti-SHANK Antibody is suitable for use in WB, Immunochemistryand IP. Expect a band approximately ~160kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

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Catalog Number: (RL609-1616)

Supplier: Rockland Immunochemical

Description: Suitable for immunoblotting (western or dot blot), ELISA, immunoelectron microscopy and immunochemistry as well as other antibody based enzymatic assays requiring lot-to-lot consistency.

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Supplier: Tonbo Biosciences

Description: The 104 antibody reacts with mouse CD45.2, also known as Ly5.2, which is a strain-specific allelic form of the CD45 Leukocyte Common Antigen (LCA). Functionally, CD45 is a protein tyrosine phosphatase whose broad cell distribution supports a critical role in many leukocyte functions, including regulation of signal transduction and cell activation associated with the T cell and B cell receptors. 

Catalog Number: (RL603-100-007)

Supplier: Rockland Immunochemical

Description: Anti-Chicken Igm (Mu Chain) (Goat) Antibody Rhodamine Conjugated - 603-100-007 Chicken Igm (Mu Chain) Antibody Rhodamine Conjugated 1 Mg

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Catalog Number: (RL600-409-098)

Supplier: Rockland Immunochemical

Description: Suitable for immunomicroscopy and flow cytometry or FACS analysis as well as other antibody based fluorescent assays requiring lot-to-lot consistency.

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Catalog Number: (200061-512)

Supplier: Enzo Life Sciences

Description: The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

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Catalog Number: (RL714-405-002)

Supplier: Rockland Immunochemical

Description: This product has been assayed against 1.0 µg of Swine IgG in a standard capture ELISA using pNPP p-nitrophenyl phosphate as a substrate for 30 minutes at room temperature.

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Catalog Number: (75930-446)

Supplier: Rockland Immunochemical

Description: The NIPSNAP proteins comprise a family of evolutionarily well-conserved proteins with strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. NIPSNAP2, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumors. It is widely expressed and most abundant in heart and skeletal muscle. NIPSNAP proteins have been suggested to be important in vesicular transport. NIPSNAP2 antibody is predicted to not cross-react with any other members of the NIPSNAP protein family.

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Catalog Number: (RL600-144-200)

Supplier: Rockland Immunochemical

Description: Primary Goat Anti-Glutathione-S-Transferase (GST) Reacts with Pan

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Catalog Number: (RL600-401-421)

Supplier: Rockland Immunochemical

Description: Affinity purified PPAR alpha Antibody has been tested for use in ELISA and by western blot.  Expect a single band approximately 52 kDa in size corresponding to PPAR alpha by western blot in the appropriate tissue or cell lysate.

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Catalog Number: (RL603-105-002)

Supplier: Rockland Immunochemical

Description: Anti-Chicken IgG (H&L) anitbody is suitable for immunoblotting (western or dot blot), ELISA, immunoelectron microscopy and immunochemistry as well as other antibody based enzymatic assays requiring lot-to-lot consistency.

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Catalog Number: (76230-076)

Supplier: Rockland Immunochemical

Description: Anti-Monkey IgG (gamma chain) DyLight™680 conjugated antibody generated in goat detects specifically monkey IgG (gamma chain). Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75% of serum immunoglobulins. IgG binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsinization for phagocytosis. The whole IgG molecule possesses both the F(c) region, recognized by high-affinity Fc receptor proteins, as well as the F(ab) region possessing the epitope-recognition site. This DyLight™680 conjugated anti-Monkey IgG gamma chain secondary antibody is ideal for investigators who routinely perform ELISA, Sandwich ELISA, titration assays, western-blot, immunoprecipitation and more general immunoassays. When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment.

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Catalog Number: (RL002-0107)

Supplier: Rockland Immunochemical

Description: Produced through a multi-stage process that includes delipidation, salt fractionation, ion-exchange chromatography, gel filtration, and affinity chromatography. No contaminating proteins are observed when assayed at a protein concentration of 20mg/mL against anti-whole serum or anti-fragment specific antisera. All immunoglobulin fragments are prepared from highly purified, whole molecules subject to enzymatic digestion.

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Catalog Number: (76262-774)

Supplier: Rockland Immunochemical

Description: In muscle tissue, collagen serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. A collagen may be defined as a protein containing sizable domain(s) of triple-helical conformation. Type IV collagen is a major macromolecular constituent of basement membranes and can be readily isolated from basement-membrane-rich tissues or highly vascularized tissues such as the placental villi. This collagen appears to be largely restricted to structures identifiable as basement membranes. In contrast, type VI collagen appears to be prevalent in several tissues even though it has been isolated largely from placental villi preparations. The extent to which type VII and VIII collagens are distributed is not known.

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