Description: beta-2 microglobulin Monoclonal antibody, Clone: BBM.1, Host: Mouse, Species reactivity: Human, Non-human primates, Isotype: IgG2b, K, Conjugate: CF488A, Immunogen: MOLT-4 human T cell line, Synonyms: B2M, Application: IF, Size: 500 uL

Catalog Number: 75883-958

Supplier: Biotium

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Description: This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.

Catalog Number: 75962-550

Supplier: Biotium

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Description: MCAM / MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MCAM/1101, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF640R, Immunogen: Recombinant human MCAM protein, Application: Immunofluorescence, Flow cytometry, Size: 500uL

Catalog Number: 75960-704

Supplier: Biotium

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Description: Neurofilament (NF-L), Monoclonal antibody, Clone: NFL/736, Host: Mouse, Species reactivity: Chicken, Pig, Cow, Rat, Human, Isotype: IgG1 andIgG2a, kappa, Conjugate: CF488A, Immunogen: Recombinant human NEFL protein, Application: IF, IHC (formalin), Size: 500uL

Catalog Number: 75965-876

Supplier: Biotium

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Description: Thiazole orange (TO) is commonly used in reticulocyte analysis to stain residual RNA of blood cells, to stain DNA in agarose gels and capillary electrophoresis. Thiazole Orange stains the yeast nucleus, and is also able to stain bacteria and mammalian cells.

Catalog Number: 75832-818

Supplier: Biotium

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Description: Ep-CAM / CD326 Monoclonal antibody, Clone: VU-1D9, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Small cell lung carcinoma cells, Application: IF, Immunohistology (formalin), Western, FC, Size: 100uL

Catalog Number: 75893-968

Supplier: Biotium

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Description: This antibody recognizes the epsilon-chain of CD3 (Workshop V; Code: CD03.09), which consists of five different polypeptide chains (designated as γ, δ, ε, ζ, and η) with MW ranging from 16-28 kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®555 is a bright orange-red fluorescent dye (Ex/Em 555/565 nm) that is compatible with super-resolution imaging by STORM.

Catalog Number: 75895-442

Supplier: Biotium

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Description: This antibody recognizes a protein of 110 kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.

Catalog Number: 75881-806

Supplier: Biotium

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Description: This antibody recognizes a protein doublet of 20-22 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

Catalog Number: 75959-846

Supplier: Biotium

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Description: This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. This MAb is excellent for staining of formalin-fixed, paraffin-embedded breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75925-044

Supplier: Biotium

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Description: CD56 / NCAM Monoclonal antibody, Clone: 123C3.D5, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Membrane preparation of a small cell lung carcinoma, Synonyms: NCAM, Leu-19, NKH1, Size: 500 uL

Catalog Number: 75914-558

Supplier: Biotium

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Description: Cytokeratin 17 Monoclonal antibody, Clone: E3, Host: Mouse, Species reactivity: Goat, Pig, Cow, Rat, Human, Isotype: IgG2b, kappa, Conjugate: CF405S, Immunogen: The cytoskeletal fraction, Synonyms: K17, KRT17, PCHC1, Application: IF, IHC, IHC, Size: 500uL

Catalog Number: 75917-012

Supplier: Biotium

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Description: Glypican-3, Monoclonal antibody, Clone: GPC3/863, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant full-length human GPC3 protein, Synonyms: DGSX; Glypican proteoglycan 3; GPC3; GTR2-2;, Size: 500uL

Catalog Number: 75948-662

Supplier: Biotium

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Description: CD20 Monoclonal antibody, Clone: B9E9, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Isotype: IgG2a, kappa, Immunogen: Lymphoblastoid cell line Daudi, Application: IF, FC, Size: 100uL

Catalog Number: 75890-632

Supplier: Biotium

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Description: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75883-378

Supplier: Biotium

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Description: This antibody recognizes a glycoprotein of 110 kDa, identified as CD26. It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75891-520

Supplier: Biotium

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