You Searched For: Antibodies

Catalog Number: (89155-012)

Supplier: Enzo Life Sciences

Description: The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses.

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Catalog Number: (RL100-401-A03)

Supplier: Rockland Immunochemical

Description: This antibody reacts with human Cul3 by western blot and immunoprecipitation.  The antibody immunoprecipitates in vitro translated product and Protein from cell lysates (using HeLa or NIH-3T3).  An 88.9 kDa band corresponding to human Cul3 is detected.

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Catalog Number: (RL200-301-I42)

Supplier: Rockland Immunochemical

Description: Anti-Procalcitonin antibody is suitbale for use in ELISA and Western Blot. Specific conditions for reactivity should be optimized by the end user.

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Catalog Number: (75935-368)

Supplier: Rockland Immunochemical

Description: SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

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Catalog Number: (10149-784)

Supplier: Immunoreagents

Description: ImmunoReagents’ Biotinylated antibody conjugates are widely used due to their ability to enhance antibody signal in most immunoassays. Biotinylated secondary antibodies are used in most immunoassay formats (i.e., ELISA, Immunohistochemistry (IHC), and Western blotting). While Biotinylated antibodies by themselves do not produce a signal that can be visualized, biotin has a high affinity and specificity to Streptavidin/Avidin. Using ImmunoReagents’ streptavidin conjugates with biotinylated antibodies results in signal amplification.

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Catalog Number: (10151-396)

Supplier: Immunoreagents

Description: TRITC (Tetramethylrhodamine isothiocyanate) is a popular rhodamine derivative pink in color but emits a red-orange color upon Emission at 580nm. TRITC is frequently paired with FITC in double labeling experiments and conjugated antibodies are often used in immunofluorescence microscopy, flow cytometry, FLISA (fluorescent ELISA) and high throughput screening assays. These conjugates are best excited with the 532 nm spectral line of the He-Ne laser and are also recommended as a second color detection reagent in in situ hybridization applications. (Excitation/Emission = 555nm / 580nm Emission Color = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, DyLight 550)

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Catalog Number: (RL605-4613)

Supplier: Rockland Immunochemical

Description: Anti-Goat IgG (H&L) Antibody has been assayed against 1.0 µg of Goat IgG in a standard capture ELISA using Peroxidase Conjugated Streptavidin and ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])

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Catalog Number: (10799-506)

Supplier: Rockland Immunochemical

Description: 5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. This results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. So far, the 5-hmC bases have been identified in Purkinje neurons, in granule cells and embryonic stem cells where they are present at high levels (up to 0,6% of total nucleotides in Purkinje cells). Preliminary results indicate that 5-hmC may have important roles distinct from 5-mC. Although its precise role has still to be shown, early evidence suggests a few putative mechanisms that could have big implications in epigenetics: 5-hydroxymethylcytosine may well represent a new pathway to demethylate DNA involving a repair mechanism converting 5-hmC to cytosine and, as such open up entirely new perspectives in epigenetic studies. Due to the structural similarity between 5-mC and 5-hmC, these bases are experimentally almost indistinguishable. Recent articles demonstrated that the most common approaches (e.g. enzymatic approaches, bisulfite sequencing) do not account for 5-hmC. The development of the affinity-based technologies appears to be the most powerful way to differentially and specifically enrich 5-mC and 5-hmC sequences. Anti-5hmC Antibody is ideal for research in Epigenetics and Gene Expression.

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Catalog Number: (RL610-703-124)

Supplier: Rockland Immunochemical

Description: Suitable for immunoblotting (western or dot blot), ELISA, immunoelectron microscopy and immunochemistry as well as other peroxidase antibody-based enzymatic assays requiring lot-to-lot consistency.

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Catalog Number: (75933-146)

Supplier: Rockland Immunochemical

Description: Troponin I (cTnI) is 1 of 3 subunits, along with troponin C (TnC) and troponin T (TnT) of troponin complex found in cardiac muscle. cTnI binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place, and when cTnI is phosphorylated by protein kinase C and protein kinase A at Ser23/24 it causes regulation of Ca2+- stimulated ATPase. Evidence suggests that phosphorylation of both serines 23 and 24 is required for the reduction in Ca2+-sensitivity and beneficial for relaxation of the heart. Ser23/24 phosphorylation is important for enhanced relaxation in response to prolonged activation of protein kinase C by endothelin in intact myocytes, while Thr144 plays an important role in the acute acceleration of relaxation. Troponin I pS23/24 Antibody is ideal for researchers interested in cancer research.

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Catalog Number: (RL600-401-384S)

Supplier: Rockland Immunochemical

Description: Anti-HA is optimally suited for monitoring the expression of HA-tagged fusion Proteins. As such, anti-HA/HA can be used to identify fusion Proteins containing the HA epitope.

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Catalog Number: (RL209-403-B93)

Supplier: Rockland Immunochemical

Description: This purified antibody has been tested for use in ELISA and western blotting. By western blot a band approximately 15 kDa in size corresponding to human IL-4 Protein is expected in the appropriate cell lysate or extract.

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Catalog Number: (RL005-0202)

Supplier: Rockland Immunochemical

Description: Produced through a multi-stage process that includes delipidation, salt fractionation, ion-exchange chromatography, gel filtration, and affinity chromatography. No contaminating proteins are observed when assayed at a protein concentration of 20mg/mL against anti-whole serum or anti-fragment specific antisera. All immunoglobulin fragments are prepared from highly purified, whole molecules subject to enzymatic digestion.

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Catalog Number: (RL200-308-M68)

Supplier: Rockland Immunochemical

Description: Anti-CD47 is useful for Flow Cytometry (Cell Surface). Researchers should determine optimal titers for applications that are not stated.

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Catalog Number: (10049-848)

Supplier: Enzo Life Sciences

Description: MyD88 (Myeloid differentiation primary response gene 88) is a general adapter protein for the Toll/IL-1R family of receptors that have been shown to induce growth arrest, terminal differentiation, and apoptosis. MyD88 plays an important role in the inflammatory response induced by cytokines, IL-1 and IL-18, and endotoxin. It has been shown that signaling via MyD88 is essential for an LPS response. MyD88 is a cytoplasmic protein, which is expressed in many tissues.

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Catalog Number: (89162-628)

Supplier: Enzo Life Sciences

Description: Host: Rabbit

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