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Description: Cystatin C is a non-glycosilated basic single-chain protein consisting of 120 amino acids with a molecular weight of 13.36 kDa and is characterized by two disulfide bonds in the carboxy-terminal region. It belongs to the cystatins superfamilly which inactivates lysosomal cysteine proteinases, e.g. cathepsin B, H,.K, L and S. Imbalance between Cystatin C and cysteine proteinases is associated with inflammation, renal failure, cancer, Alzheimer's disease, multiple sclerosis and hereditary Cystatin C amyloid angiopathy. Its increased level has been found in patients with autoimune diseases, with colorectal tumors and in patients on dyalisis. Serum Cystatin C seems to be better marker of glomerular filtration rate than creatinine. On the other hand, low concentration of Cystatin C presents a risk factor for secondary cardiovascular events.
Catalog Number: 102552-962
Supplier: BioVendor


Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
Catalog Number: 76011-126
Supplier: Prosci


Description: Lightweight, two-level step stool for the cleanroom
Catalog Number: 24450-004
Supplier: Bandy

Small Business Enterprise Minority or Woman-Owned Business Enterprise Product available on GSA Advantage®


Description: These gloves are heavy yet surprisingly sensitive.
Catalog Number: 102091-214
Supplier: Electron Microscopy Sciences


Description: Design Line scissors feature heavy-gauge, polished stainless steel blades with an inside edge and bevel grinds
Catalog Number: 500024-467
Supplier: Janitorial Supplies


Description: Guide students through dissection with this representation of the common frog. Designed in three-dimensions, the models show a dorsal view and all internal viscera.
Catalog Number: 470136-024
Supplier: Wards


Description: Cy3 is one of the most popular fluorescent labeling dyes for preparing orange-red fluorescent bioconjugates.
Catalog Number: 76484-488
Supplier: AAT BIOQUEST INC

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Description: Cy5 is one of the most popular fluorescent labeling dyes for preparing orange-red fluorescent bioconjugates.
Catalog Number: 76484-490
Supplier: AAT BIOQUEST INC

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Description: The illustra GFX PCR DNA and Gel Band Purification kits are for the isolation and concentration of DNA fragments from PCR mixtures, DNA-containing agarose gel bands, enzyme-based DNA modifications, and restriction enzyme digests.
Catalog Number: 95026-728
Supplier: GE Healthcare - Life Sciences

Description: Tough, flexible nitrile (NBR) coating over a cotton jersey liner provides superior cut, puncture, snag, and abrasion resistance.
Catalog Number: 47742-276
Supplier: Showa

Product available on GSA Advantage®


Description: Even the dirtiest, harshest jobs won't destroy the will of these tough gloves.
Catalog Number: 80081-562
Supplier: MCR Safety


Description: For use with the Single Tube Holder (12620-898) to allow hands-free, single tube mixing on mixers.
Catalog Number: 12620-898
Supplier: VWR International

Description: Cy7 is one of the most popular fluorescent labeling dyes for preparing orange-red fluorescent bioconjugates.
Catalog Number: 76484-492
Supplier: AAT BIOQUEST INC

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Description: This protein is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
Catalog Number: 89357-984
Supplier: Genetex


Description: 7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.
Catalog Number: 77439-240
Supplier: Bioss


Description: EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kB-activating branch.
Catalog Number: 10802-582
Supplier: Rockland Immunochemical


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