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Catalog Number: (77700-582)
Supplier: AFG BIOSCIENCE LLC
Description: WB:1:500-1:2000, IHC:1:100-1:300, ELISA:1:20000

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Supplier: TCI America
Description: (stabilized with Copper chip) CAS Number: 615-37-2 MDL Number: MFCD00001042 Molecular Formula: C7H7I Molecular Weight: 218.04 Purity/Analysis Method: <gt/>98.0% (GC) Form: Clear Liquid Boiling point (°C): 211 Flash Point (°C): 90 Specific Gravity (20/20): 1.72

SDS

Catalog Number: (76854-072)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to GSTA2 for WB with samples derived from Human, Mouse and Rat.


Supplier: QUANTUM STORAGE SYSTEMS
Description: Easy access to stored items with hopper front bin and label holder provides fast identification

Supplier: THERMO FISHER SCIENTIFIC CHEMICALS
Description: Bromoform 96% stabilized

Catalog Number: (10372-582)
Supplier: Bioss
Description: Smad2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor-regulated Smad's, activin/TGF alpha receptor-regulated (Smad2 and 3) or BMP receptor regulated (Smad1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smad's; and the inhibitory Smad's, (Smad6 and Smad7). Smad2 consists of two highly conserved domains, the N terminal Mad homology (MH1) and the C-terminal Mad homology 2 (MH2) domains. The MH1 domain binds DNA and regulates nuclear import and transcription while the MH2 domain conserved among all the Smad's regulates Smad2 oligomerization and binding to cytoplasmic adaptors and transcription factors. Activated Smad2 associates with Smad4 and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. This translocation of Smad2 (as well as Smad3) into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin binding region of the MH1 domain by extracellular signal regulated kinase 1(ERK 1) enhances Smad2 transcriptional activity, which is negatively regulated by calmodulin. The regulation of Smad2 phosphorylation on threonine 8 by ERK 1 and calmodulin is critical for Smad2 mediated signaling.


Supplier: VWR
Description: Stacking kit for White Diamond undercounter /countertop refrigerators and freezers (PF021WWW/0M, PF021WWWLH/0M, PF021WWW/0A, PF021WWWLH/0A, FR051WWW/0, FF051WWW/0M)

Catalog Number: (76731-754)
Supplier: ANTIBODIES.COM LLC
Description: Human Siah2 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human Siah2 in serum, plasma, tissue homogenates, and other biological fluids.


Catalog Number: (77987-434)
Supplier: LGC STANDARDS
Description: Isopropyl Ether (Stabilized with BHT), TRC, LGC Standards

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Catalog Number: (89387-932)
Supplier: Abgent


Catalog Number: (89304-516)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to Smad2 (Phospho Ser467)


Catalog Number: (470119-196)
Supplier: American 3B Scientific
Description: Anatomical Representation Of Human Birth


Catalog Number: (10069-036)
Supplier: Prosci
Description: Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma.


Catalog Number: (76010-862)
Supplier: Prosci
Description: SMAP2 is a GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).


Catalog Number: (10372-576)
Supplier: Bioss
Description: Smad2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor-regulated Smad's, activin/TGF alpha receptor-regulated (Smad2 and 3) or BMP receptor regulated (Smad1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smad's; and the inhibitory Smad's, (Smad6 and Smad7). Smad2 consists of two highly conserved domains, the N terminal Mad homology (MH1) and the C-terminal Mad homology 2 (MH2) domains. The MH1 domain binds DNA and regulates nuclear import and transcription while the MH2 domain conserved among all the Smad's regulates Smad2 oligomerization and binding to cytoplasmic adaptors and transcription factors. Activated Smad2 associates with Smad4 and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. This translocation of Smad2 (as well as Smad3) into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin binding region of the MH1 domain by extracellular signal regulated kinase 1(ERK 1) enhances Smad2 transcriptional activity, which is negatively regulated by calmodulin. The regulation of Smad2 phosphorylation on threonine 8 by ERK 1 and calmodulin is critical for Smad2 mediated signaling.


Catalog Number: (77566-272)
Supplier: AMBEED, INC
Description: Methyl 2-cyanoacrylate ≥98% stabilized

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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