You Searched For: ST. GOBAIN - CLEARWATER

Description: Members of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.

Catalog Number: 10390-482

Supplier: Bioss

Sale

Description: Members of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.

Catalog Number: 10390-480

Supplier: Bioss

Sale

Description: Environmentally friendly cutlery is heat tolerant up to 220°F

Catalog Number: 500015-509

Supplier: Janitorial Supplies

Sale

Description: Hamilton Company offers one of the most comprehensive selections of chromatography columns in the industry.

Catalog Number: 89221-128

Supplier: Hamilton

Sale

Description: 200.7 Rev. 4.4 - Calibration Standard 1: Ag @ 50; B, Ba, Be, Cd, Ce, Co, Cr, Cu, Mn, Ni, Pb, Sr, V @ 200; As, Se, Tl, Zn @ 500; Ca, K, Mg, P @ 1000 µg/mL in 5% HNO3, VHG, LGC Standards

Catalog Number: 77692-992

Supplier: LGC STANDARDS

New Product Sale

Description: VWR® Mega Star 600 Ventilated and 600R Refrigerated Small Bench Centrifuge optimize bench space with maximized capacity in a compact footprint. Available in both a ventilated and refrigerated option, units come with a user-friendly interface and are adaptable in the ever evolving clinical and research laboratory.

Catalog Number: 76533-882

Supplier: VWR International

Sale

Description: Starsys® Undercounter Storage Carts enhance productivity and space efficiency.

Catalog Number: 76463-292

Supplier: Metro

Sale

Description: Heavy-duty hamper stands are made from ⁷/₈" chrome-plated steel tubing with a lower support platform. They are ideal for heavyweight applications.

Catalog Number: 76359-050

Supplier: Medegen Medical Products, LLC

Sale

Description: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

Catalog Number: 10352-388

Supplier: Bioss

Sale

Description: Anti-STAT3 Rabbit Polyclonal Antibody

Catalog Number: 220011-716

Supplier: R&D Systems

Sale

Description: Essential for today's public spaces, a complete hand sanitizer unit that includes the stand and motion-activated, touchless gel dispenser.

Catalog Number: 470327-952

Supplier: Diversified Woodcrafts

Sale

Description: Rabbit polyclonal antibody to Smad3 (phospho Ser213) for WB and ELISA with samples derived from Human, Mouse and Rat.

Catalog Number: 77043-794

Supplier: ANTIBODIES.COM LLC

Sale

Description: Signal transducer and activator of transcription 3 (Stat3) belongs to a family of cytoplasmic transcription factors that can be activated by phosphorylation by its cell surface receptor. Stat3 plays a key role in many cellular processes such as cell growth and apoptosis. It also mediates cellular responses to interleukins, KITLG/SCF,EGF, IFN-alpha and other growth factors and may mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Stat3 forms a homodimer or a heterodimer with a related family member (e.g. STAT1). Activation occurs through phosphorylation of tyrosine 705 and serine 727. Phosphorylation of Stat3 at Tyr705 induces Stat3 dimerization and nuclear translocation. Serine phosphorylation is important for stable DNA-binding of Stat3 homodimers and maximal transcriptional activity. Stat3 can have a dual role in cancer, it has been found that Stat3 protein can promote oncogenesis and have a tumor suppressor role depending upon the mutational background of the tumor.

Catalog Number: 75932-192

Supplier: Rockland Immunochemical

Sale

Description: Rabbit polyclonal antibody to Smad3 for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.

Catalog Number: 77051-668

Supplier: ANTIBODIES.COM LLC

Sale

Description: Rabbit Polyclonal antibody to hnRNP A/B (heterogeneous nuclear ribonucleoprotein A/B)

Catalog Number: 89318-568

Supplier: Genetex

Sale

Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of STAT3.

Catalog Number: 10675-398

Supplier: Abnova

Sale