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Catalog Number: (102681-066)
Supplier: Electron Microscopy Sciences
Description: A heavy duty stand, offering quick and easy attachment of the Bio-Pump


Catalog Number: (77440-010)
Supplier: Bioss
Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.


Catalog Number: (10368-898)
Supplier: Bioss
Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.


Catalog Number: (77700-585)
Supplier: AFG BIOSCIENCE LLC
Description: WB:1:500-1:2000, IHC:1:100-1:300, ELISA:1:10000

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Catalog Number: (77700-586)
Supplier: AFG BIOSCIENCE LLC
Description: WB:1:500-1:2000, IHC:1:100-1:300, ELISA:1:20000

New Product


Catalog Number: (89304-520)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to Smad3 (Phospho Ser425)


Catalog Number: (470348-346)
Supplier: INKSMITH LIMITED SE
Description: Accessories for InkSmith Mako Laser Cutter (60 Watt)


Catalog Number: (60942-616)
Supplier: Abgent
Description: Purified Rabbit Polyclonal Antibody (Pab). This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human SMAD3. Specificity: H. Concentration: 0.25 mg/ml. Size: 0.1 mg.


Catalog Number: (89310-582)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))


Catalog Number: (76078-268)
Supplier: Bioss
Description: Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.


Catalog Number: (33501-428)
Supplier: Chemglass
Description: Floor style stainless steel support stands.

Small Business Enterprise


Catalog Number: (77776-343)
Supplier: Caframo
Description: The Caframo Safety Stand offers stable support for all Caframo stirrers.


Catalog Number: (500025-392)
Supplier: Janitorial Supplies
Description: Adjustable stand made from durable powdercoated steel mesh construction positions laptop at personal viewing levels, reducing glare and neck and eye strain and fatigue.

Environmentally Preferable


Supplier: Janitorial Supplies
Description: Large surface provides ample space for most printers and fax machines

Catalog Number: (500041-544)
Supplier: Janitorial Supplies
Description: Raises monitor to a comfortable height, making typing and viewing easier on your back and neck.


Catalog Number: (500025-391)
Supplier: Janitorial Supplies
Description: Places the laptop at a comfortable height to maximize efficiency.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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