You Searched For: stab1


2,849  results were found

SearchResultCount:"2849"

Sort Results

List View Easy View (new)

Rate These Search Results

Catalog Number: (10370-780)
Supplier: Bioss
Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.


Catalog Number: (102238-438)
Supplier: Novus Biologicals
Description: Integrin beta 1 Lysate (Adult Normal)


Catalog Number: (10268-692)
Supplier: Bioss
Description: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.


Catalog Number: (10370-784)
Supplier: Bioss
Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.


Catalog Number: (102163-328)
Supplier: Novus Biologicals
Description: The Recombinant Human GSTA1 Protein from Novus Biologicals is derived from E. coli. The Recombinant Human GSTA1 Protein has been validated for the following applications: Functional, SDS-Page, Bioactivity.


Catalog Number: (10113-142)
Supplier: Prosci
Description: Polyclonal, Host: Goat, Species Reactivity: Human, Mouse, Rat, Immunogen: OTUB1 antibody was raised against a 14 amino acid synthetic peptide near the internal region of OTUB1, Tested Applications: ELISA, WB


Catalog Number: (102151-292)
Supplier: Novus Biologicals
Description: SMAD1 Overexpression Lysate (Adult Normal)


Catalog Number: (102212-320)
Supplier: Novus Biologicals
Description: The SETDB1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SETDB1. This antibody reacts with human. The SETDB1 Antibody has been validated for the following applications: Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (102246-648)
Supplier: Novus Biologicals
Description: Integrin beta 1 Lysate (Adult Normal)


Catalog Number: (102189-038)
Supplier: Novus Biologicals
Description: The SAAL1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SAAL1. This antibody reacts with human. The SAAL1 Antibody has been validated for the following applications: Western Blot.


Catalog Number: (89321-834)
Supplier: Genetex
Description: Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: IHC-P, WB Pkg Size: 100 ul


Catalog Number: (TS20246-0250)
Supplier: THERMO FISHER SCIENTIFIC CHEMICALS
Description: Hydrogen peroxide 35% (w/w) in water stabilized for analysis


Catalog Number: (TS364320010)
Supplier: THERMO FISHER SCIENTIFIC CHEMICALS
Description: Chloroform, extra dry over Molecular Sieve 99.9% stabilized, AcroSeal™

New Product


Catalog Number: (76110-830)
Supplier: Bioss
Description: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3 appears to be activated by both while Stat3 is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.


Catalog Number: (ABCA_AB303133-100U)
Supplier: ABCAM INC.
Description: Anti-STUB1/CHIP Rabbit Monoclonal Antibody [clone: EPR4447] (HRP)

New Product


Catalog Number: (104027-596)
Supplier: ALKALI SCIENTIFIC MS
Description: Enhance organization with Alkali Scientific™ ProCycle™ 0.2 ml rigid stable 8-Strip PCR tubes with attached individual flat caps, available in assorted colors for easy sample identification.


Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • State issued document with your organization's Federal Tax ID Number
  • State issued document with your organization's Resale Tax ID Number
  • City or County issued Business License
  • State Department of Health Services License
  • Any other ID issued by the State that includes the business name and address

* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
481 - 496 of 2,849
no targeter for Bottom