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Catalog Number: (10268-696)
Supplier: Bioss
Description: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.


Catalog Number: (10288-472)
Supplier: Bioss
Description: Chymotrypsins are digestive enzymes that can perform proteolysis by cleaving peptides at the carboxyl side of tyrosine, tryptophan, leucine and phenylalanine, although over time they can also hydrolyze other amide bonds, especially those with leucine-donated carboxyls. Chymotrypsins cleave peptide bonds by attacking the non-reactive carbonyl group with a powerful nucleophile, which momentarily becomes covalently bonded to the substrate to form an intermediate. Chymotrypsin B (CTRB1) and Chymotrypsin B2 (CTRB2) are synthesized in the pancreas by protein biosynthesis as precursors that are enzymatically inactive, but become active as three polypeptide molecules that are interconnected by disulfide bonds.


Catalog Number: (10162-490)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to SMAD1


Catalog Number: (102246-212)
Supplier: Novus Biologicals
Description: SETDB1 Lysate (Adult Normal)


Catalog Number: (102150-628)
Supplier: Novus Biologicals
Description: SAAL1 Overexpression Lysate (Adult Normal)


Catalog Number: (10168-144)
Supplier: Genetex
Description: Mouse Monoclonal Antibody [6D2] to SNAI1


Catalog Number: (89515-896)
Supplier: Abgent
Description: Western Blot: 1:1000


Catalog Number: (10370-776)
Supplier: Bioss
Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.


Catalog Number: (102118-090)
Supplier: Novus Biologicals
Description: The SETDB1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SETDB1. This antibody reacts with human. The SETDB1 Antibody has been validated for the following applications: Western Blot, Immunoprecipitation, Proximity Ligation Assay.


Catalog Number: (102209-860)
Supplier: Novus Biologicals
Description: SATB2 Peptide. Tested Applications: Blocking/Neutralizing. Tested Reactivity: Human.


Catalog Number: (89515-358)
Supplier: Abgent
Description: polyclonal antibody Isotype: Rabbit Ig, Species Reactivity: human, Gene ID: 3688, Target/specificity: This ITGB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 759-785 amino acids from the C-terminal region of human ITGB1.


Catalog Number: (10094-386)
Supplier: Proteintech
Description: SETDB1, also named as ESET, KIAA0067 and KMT1E, belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation, gene silencing, and transcriptional repression. It has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SETDB1.


Catalog Number: (102235-192)
Supplier: Novus Biologicals
Description: SIAH1 Lysate (Adult Normal)


Catalog Number: (89514-694)
Supplier: Abgent
Description: Western Blot: 1:1000


Catalog Number: (10251-874)
Supplier: Bioss
Description: OTUB1 is a 271 amino acid protein that contains one OTU (ovarian tumor) domain and belongs to the OTU family of predicted cysteine proteases. Expressed as two isoforms (one of which is present throughout the body and the other of which is present only in lymphoid tissues), OTUB1 functions as a hydrolase that can remove ubiquitin residues from target proteins, thereby preventing protein degradation and playing an important role in protein turnover. OTUB1 interacts with GRAIL and, via this interaction, plays a role in the regulation and the induction of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to their cognate antigens. Due to its interaction with GRAIL, OTUB1 is an important regulator of immune responses in secondary lymphoid organs.


Catalog Number: (102160-166)
Supplier: Novus Biologicals
Description: The Otubain-1 Antibody from Novus Biologicals is a goat polyclonal antibody to Otubain-1. This antibody reacts with mouse. The Otubain-1 Antibody has been validated for the following applications: Western Blot, Peptide ELISA.


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