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Description: Anti-IgG Goat Polyclonal Antibody (CF™ 640R)

Catalog Number: 71003-908

Supplier: Biotium

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Description: CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellularscavenger receptor cysteine-rich(SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

Catalog Number: 75917-202

Supplier: Biotium

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Description: TAG-72 / CA72.4, Monoclonal antibody, Clone: CA72/733, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 100uL

Catalog Number: 75974-814

Supplier: Biotium

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Description: CD45RB Monoclonal antibody, Clone: PTPRC/1147, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recom full-length human CD45RB protein, Synonyms: B220, CD45R, Application: IF, IHC, WB, FC, Size: 500 uL

Catalog Number: 75911-632

Supplier: Biotium

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Description: Cytokeratin 7 Monoclonal antibody, Clone: K72.7, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: biotin, Immunogen: Semi-purified cytokeratin preparation, Synonyms: CK-7, K2C7, Keratin 55K Type II, Application: IF, IHC, FC, Size: 100uL

Catalog Number: 75920-086

Supplier: Biotium

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Description: Cytokeratin 10 Monoclonal antibody, Clone: KRT10/844, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recom human KRT10 protein, Synonyms: BCIE, BIE, EHK, Application: IF, IHC, FC, Size: 100uL

Catalog Number: 75918-284

Supplier: Biotium

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Description: This antibody recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). Its epitope localizes between aa SITTTE. This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75962-210

Supplier: Biotium

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Description: CD8 Monoclonal antibody, Clone: C8/144B, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: BSA-free, Immunogen: A 13 amino acid peptide from C-terminal cytoplasmic domain, Synonyms: Ly3, LYT3, MAL, Application: IF, IHC, FC, Size: 50 uL

Catalog Number: 75907-902

Supplier: Biotium

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Description: Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, with 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 55 kDa (CK7); 52 kDa (CK8); 56.5 kDa (CK10); 53 kDa (CK13); 50 kDa (CK14); 50 kDa (CK15); 48 kDa (CK16); 46 kDa (CK17); 45 kDa (CK18) and 40 kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. KRT-PAN is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It is useful in characterizing the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and shows high sensitivity in the recognition of epithelial cells and carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75968-042

Supplier: Biotium

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Description: Ep-CAM / CD326 Monoclonal antibody, Clone: EGP40/1120, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Recombinant full-length human EpCAM protein, Application: IF, Immunohistology, Western, FC, Size: 500 uL

Catalog Number: 75893-536

Supplier: Biotium

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Description: HSP60, Monoclonal antibody, Clone: GROEL/730, Host: Mouse, Species reactivity: Mouse, Hamster, Monkey, Pig, Dog, Cow, Sheep, Rat, Human, Chicken, Rabbit, Isotype: IgG1, kappa, BSA-free, Immunogen: Recombinant human HSPD1 protein, Application: Immunofluorescence, Size: 50 uL

Catalog Number: 75953-430

Supplier: Biotium

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Description: MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF, D5, recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.

Catalog Number: 75961-470

Supplier: Biotium

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Description: This MAb recognizes a protein of ~50 kDa which is identified as Glial Fibrillary Acidic Protein (GFAP). It shows no cross-reaction with other intermediate filament proteins. GFAP is specifically found in astroglia. GFAP is a very popular marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. Antibody to GFAP is useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentiation in tumors outside the CNS.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75927-446

Supplier: Biotium

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Description: Bax Monoclonal antibody, Clone: 2D2, Host: Mouse, Species Reactivity: Human, Monkey, Isotype: IgG1, Conjugate: CF647, Immunogen: Recognizes a protein of 21kDa, Application: Immunofluorescence, Immunohistology (formalin), Western, Flow cytometry, Size: 100ul

Catalog Number: 75884-372

Supplier: Biotium

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Description: PLAP (Placental Alkaline Phosphatase), Monoclonal antibody, Clone: ALP/870, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF647, Immunogen: Recombinant full-length human ALPP protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL

Catalog Number: 75970-258

Supplier: Biotium

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Description: Mucin 1 / EMA / Episialin / CD227, Monoclonal antibody, Clone: GP1.4, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Human milk-fat globule membranes (HMFGM), Application: IF, Size: 100uL

Catalog Number: 75963-492

Supplier: Biotium

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