You Searched For: pressure+hose

Supplier: Bachem Americas

Description: Intermedins are members of the calcitonin/CGRP family. In vitro studies have shown that the synthetic 47 amino acid intermedin peptides act through the calcitonin receptor-like receptor/receptor activity-modifying protein (CRLR/RAMP) complexes by increasing intracellular cAMP levels. Unlike calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM) intermedin exhibited no preference for one of the three RAMPs when co-expressed with CRLR. In normal and spontaneously hypertensive rats it has been demonstrated that intermedin treatment results in blood pressure reduction which can be blocked by the CGRP receptor antagonist CGRP (8-37). Apart from the hypotensive action, synthetic intermedin has also been shown to inhibit gastric emptying and food intake in mice. Therefore, intermedin represents an additional regulator of gastrointestinal and cardiovascular functions and might be involved in other bioactivities mediated by the CRLR/RAMP receptor complexes

Catalog Number: (H-6068.0500BA)

Supplier: Bachem Americas

Description: Intermedins are members of the calcitonin/CGRP family. In vitro studies have shown that the synthetic 47 amino acid intermedin peptides act through the calcitonin receptor-like receptor/receptor activity-modifying protein (CRLR/RAMP) complexes by increasing intracellular cAMP levels. Unlike calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM) intermedin exhibited no preference for one of the three RAMPs when co-expressed with CRLR. In normal and spontaneously hypertensive rats it has been demonstrated that intermedin treatment results in blood pressure reduction which can be blocked by the CGRP receptor antagonist CGRP (8-37). Apart from the hypotensive action, synthetic intermedin has also been shown to inhibit gastric emptying and food intake in mice. Therefore, intermedin represents an additional regulator of gastrointestinal and cardiovascular functions and might be involved in other bioactivities mediated by the CRLR/RAMP receptor complexes

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Catalog Number: (10073-188)

Supplier: Prosci

Description: BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. BNP circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. It is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic.

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Catalog Number: (10258-734)

Supplier: Bioss

Description: QRFP is a 136 amino acid secreted protein that is widely expressed in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis and thyroid, QRFP is a member of the RFamide neuropeptide family. QRFP may be involved in aldosterone secretion by the adrenal gland and is also implicated in stimulating metabolic rate, locomotor activity and increasing blood pressure. Considered a ligand for the G-protein coupled receptor GPR103, QRFP may have orexigenic activity, thereby acting as an appetite stimulant. The gene encoding QFRP is located on human chromosome 9, which consists of about 145 million bases, comprises roughly 4% of the human genome and encodes nearly 900 genes.

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Catalog Number: (10242-212)

Supplier: Bioss

Description: Angiotensin Converting enzyme is involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilatator. ACE exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.

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Supplier: YMC America,Inc

Description: YMC-Triart C18, 5 µm is a novel, organic/inorganic hybrid silica particle derivatized with C18 (L1 USP designation).

Catalog Number: (76116-782)

Supplier: Bioss

Description: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared to isoform 1.

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Catalog Number: (10315-598)

Supplier: Bioss

Description: G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity.

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Catalog Number: (10390-822)

Supplier: Bioss

Description: PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.

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Catalog Number: (10390-820)

Supplier: Bioss

Description: PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.

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Catalog Number: (490009-278)

Supplier: Labnet International

Description: Labnet's AccuSeal Semi Automated Plate Sealer is ideal for the low to medium throughput Laboratory that requires uniform and consistent sealing of microplates. Offering complete versatility, the AccuSeal will accept a full range of plates for PCR, assay or storage applications, and can be used for standard height to deep well plates. Operation is easy, sealing parameters are set and displayed via the user-friendly control panel, and the sealing operation is automated to ensure consistent results. Controls and Operation - The AccuSeal's Control System features an intuitive layout, and allows optimal settings for all types of plates and sealing material. Press the MODE button to choose Sealing Time, or Sealing Temperature, and use the convenient turn knob to change settings. Temperature can be precisely set in increments of 1.0°C, and time in increments of 0.1 seconds. The AccuSeal also features a No Heat setting for pressure sealing applications.

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Supplier: Restek

Description: Intermediate-polarity deactivated guard/retention gap columns are useful for a wide range of applications and are proven to be compatible with most common solvents.

Catalog Number: (97067-840)

Supplier: GE Healthcare - Life Sciences

Description: HiScreen™ Capto™ Blue is prepacked with the base matrix Capto™ to which cibacron blue 3G is covalently bound via a hydrophilic spacer immobilised with a stable amine bond.

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Supplier: Kemtech America

Description: These vacuum take-off adapters have a short stem.

Catalog Number: (76031-688)

Supplier: SOLVENTUM PURIFICATION INC

Description: 3M™ High Flow Series System for Ice Applications, Model ICE260-S provides consistent high quality water by reducing particulate, chlorine taste and odor, cyst*, bacteria1, and scale**. The Sanitary Quick Change (SQC) design allows for easy cartridge change-outs.

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Supplier: HITACHI HIGH-TECH AMERICA, INC.

Description: The Chromaster HPLC system has established new limits in performance, ease of use, and robustness. Its design incorporates an extremely low dwell volume and a very low carry-over. In combination with very sensitive detector technology, especially the fluorescence detector, the Chromaster HPLC system is one of the strongest LC systems on the market. A huge amount of accessories and a modular set-up, enable an easy adaption to all customer needs, whether if it is used for an aggressive industrial or a high sensitive pharma application. VWR's relationship with Hitachi started over 30 years ago as a Merck Hitachi cooperation. During this time, the robustness and reliability of the Hitachi HPLC instruments has helped to build and develop a strong partnership.