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Apicidin ≥98% (by HPLC, TLC)

Supplier: Adipogen
Description: Antiprotozoal. Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest at the G1 phase. Induces hyperacetylation of histone H4. Apoptosis inducer. Potent anti-angiogenic compound. Decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines. Autophagy inducer in oral squamous cell carcinoma (OSCC) cells. Promotes either self-renewal or differentiation of embryonic stem cells.

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SURGIFOAM® Absorbable Gelatin Oral Sponge, ETHICON

Supplier: Healthcare Products
Description: The SURGIFOAM® absorbable gelatin sponge, U.S.P. is a sterile, water-insoluble, malleable, porcine gelatin absorbable sponge intended for hemostatic use by applying to a bleeding surface. The sponge is off-white and porous in appearance.

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Lapatinib ≥95%

Supplier: Adipogen
Description: Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor, with IC(50) values of 10.8 and 9.2nM respectively. It is an orally active drug for treatment of breast cancer and other solid tumors.

Product Image-10195-004

Long Stitch Scissors, OR Grade, Sklar

Catalog Number: (10195-004)
Supplier: Sklar
Description: Sklar's Long Stitch Scissors are used for suture removal
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Ibrutinib ≥98%

Supplier: Adipogen
Description: Potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM).

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L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethylester

Supplier: Bachem Americas
Description: E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer's disease animal models.

Product Image-BD351185

Falcon® HTS 24-Multiwell Insert Systems, Corning

Supplier: Corning
Description: The Falcon® HTS 24-multiwell insert system is designed to automate many commonly used membrane-based cell assays and increase the productivity and throughput of these assays in the drug discovery process. Available in a choice of membrane pore sizes (1, 3 and 8 µm), 24-multiwell inserts have been successfully used for a variety of applications including permeability studies for oral bioavailability and absorption studies (Caco-2 cells), chemotaxis, cell migration and invasion assays.

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Anti-Zinc-alpha-2-glycoprotein Rabbit Polyclonal Antibody

Catalog Number: (10083-430)
Supplier: Proteintech
Description: Zinc-alpha-2-glycoprotein (AZGP1) is a soluble protein normally found in body fluids, functions as a lipid mobilizing factor . It is known to be expressed in the secretory epithelia of the liver, lung, breast, GI tract and sweat glands, sharing significant structural similarity with the class I major histocompatibility complex (MHC) antigens . AZGP1 is involved in carcinogenesis and differentiation. Altered expression of AZGP1 has been reported in breast cancer, prostate cancer and lung adenocarcinoma, hepatocellular carcinoma, pancreatic carcinoma and oral tumors .
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Human Recombinant EMMPRIN (from Cells)

Catalog Number: (75789-454)
Supplier: Prosci
Description: Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen beta -chain. EMMPRIN is a transmembrane glycoprotein with different forms, resulting from different modes of glycosylation and N-terminal sequence variants. EMMPRIN can be expressed in breast cancer, oral squamous cell carcinoma, glioma, lymphoma, lung, bladder, and melanoma carcinomas cells. EMMPRIN promotes invasion, metastasis, growth, and survival of malignants cells, serves as a receptor for extracellular cyclophilinthe, may play a role in signal transduction.
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Hydroxypropyl methylcellulose (Hypromellose), 50 mPa.s USP Substitution Type 2910

Supplier: Spectrum Chemicals
Description: Hypromellose, Substitution Type 2910, 50 mPa.s, USP. 

Certificates Small Business Enterprise

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JNJ-38877605 ≥95%

Supplier: Adipogen
Description: JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229 other kinases tested).

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Hydroxypropyl methylcellulose (Hypromellose), 4000 mPa.s USP Substitution Type 2910

Supplier: Spectrum Chemicals
Description: Hypromellose, Substitution Type 2910, 4000 mPa.s, USP is a semisynthetic, viscoelastic polymer that is inert and used as an ophthalmic lubricant, a controlled-delivery component and an excipient in oral medicaments. It is also used as a food additive and acts as an emulsifier, suspending agent and thickening agent. Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities

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Product Image-10094-080

Anti-S100 A14 Rabbit Polyclonal Antibody

Catalog Number: (10094-080)
Supplier: Proteintech
Description: The S100 family is a multifunctional group of EF-hand type calciumbinding proteins. S100A14 protein (previously known as BCMP84, S100A15) is a recently identified member of the S100 family. It is differentially expressed in a number of different human malignancies like ovary, breast, uterus, kidney, rectum and colon cancers, and esophageal and oral squamous cell carcinomas (OSCCs).
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Anti-SERPINB13 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76108-532)
Supplier: Bioss
Description: Headpin is a skin-specific, UV-repressible serine proteinase inhibitor (serpin) belonging to the ovalbumin serpin family. Headpin is abundant in the human keratinocyte cell line HaCaT, and in lesional keratinocytes from psoriatic skin. Headpin downregulation occurs in squamous cell carcinoma of the oral cavity and in squamous cell carcinoma cell lines of the head and neck.
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Tribehenin

Supplier: Spectrum Chemicals
Description: Glyceryl Behenate, also known as Glycerol docosanoate, is a fat that is used as a viscosity-increasing agent in emulsions in foods & cosmetics, and as a tablet and a lubricant & lipidic coating excipient in oral pharmaceutical formulations.

Certificates Small Business Enterprise

Product Image-76303-034

Sterile Microscope Slides, Azer Scientific

Catalog Number: (76303-034)
Supplier: Azer Scientific Inc.
Description: Sterilized microscope slides feature a single frosted end marking area.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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