You Searched For: oral+medication

Catalog Number: (10749-926)

Supplier: Prosci

Description: SLPI Antibody: Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kappa B activation by inhibiting Ikappa B degradation in the cytoplasm and competing for NF-kappa B binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.

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Supplier: Adipogen

Description: XL388 is a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR) with an IC(50) of 9.9nM.

Supplier: Adipogen

Description: GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner.

Supplier: Adipogen

Description: PF04217903 is a novel orally bio-available, small molecule tyrosine kinase inhibitor with potential anti-neoplastic activity. It is an extremely selective MET inhibitor, with an IC(50) of 4.8nM.

Supplier: Adipogen

Description: Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC(50) values of 59nM and 92nM for HER2 and EGFR, respectively. It is in development for the treatment of early- and late-stage HER2-positive breast cancer.

Supplier: Spectrum Chemicals

Description: meso-Erythritol is a four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator. It is used in cosmetic and personal care products as a humectant and skin conditioning agent with moisturizing properties. It is used in skin care, oral care, cleansers, and toners. It is easily soluble in cold water

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Supplier: Adipogen

Description: E7080 is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. It is most potent against VEGFR2(KDR)/VEGFR3(Flt-4), with IC(50) values of 4nM and 5.2nM respectively.

Supplier: Adipogen

Description: Orally bioavailable potent antitumor, antiangiogenic, antiproliferative and antineoplastic agent. Multi-target kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRbeta, Kit, RET and Raf-1 with IC50 values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively.

Supplier: Adipogen

Description: CYC116 is an orally active small molecule multi-kinase inhibitor with anti-neoplastic activity. CYC116 inhibits Aurora kinases A/B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.

Supplier: Adipogen

Description: CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has <gt/>640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met.

Supplier: Adipogen

Description: Gefitinib is a selective, orally available epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. In NR6wtEGFR and NR6W cells, it inhibits Tyr1173, Tyr992, Tyr1173 and Tyr992 with IC(50) values of 37nM, 37nM, 26nM and 57nM, respectively.

Supplier: Adipogen

Description: SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. It is 38 times more potent against p38alpha MAP kinase (IC(50) of 3.2nM) over p38beta MAP kinase (IC(50) of 122nM).

Supplier: Adipogen

Description: Masitinib is a potent, orally available protein tyrosine kinase inhibitor targeting c-Kit, PDGFR and FGFR3. It demonstrates activity for Kit and PDGFRalpha/beta with IC(50) values of 200nM, 540nM and 800nM respectively. It shows weak inhibition of ABL and c-Fms.

Supplier: Adipogen

Description: PI3Kgamma is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Kgamma IC(50) 29nM, AKT IC(50) 294nM.

Catalog Number: (10242-358)

Supplier: Bioss

Description: Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.

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Catalog Number: (76100-834)

Supplier: Bioss

Description: Human Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 16 and 18 seem to be responsible for the development of some carcinoma like cervical carcinoma.

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