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Catalog Number: (89359-082)
Supplier: Genetex
Description: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.


Catalog Number: (89296-486)
Supplier: Genetex
Description: Goat polyclonal antibody to APOBEC1


Catalog Number: (89267-090)
Supplier: Genetex
Description: Rabbit polyclonal antibody to SMG5 (N-terminal)


Catalog Number: (10337-512)
Supplier: Bioss
Description: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.


Catalog Number: (76002-114)
Supplier: Enzo Life Sciences
Description: From <i>Corynebacterium diphtheriae</i>.


Catalog Number: (89270-652)
Supplier: Genetex
Description: Rabbit polyclonal antibody to APOBEC3F (N-terminal)


Catalog Number: (77440-820)
Supplier: Bioss
Description: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.


Catalog Number: (10105-460)
Supplier: Prosci
Description: PLRG1 is necessary for spliceosome assembly and for pre-mRNA splicing.


Catalog Number: (89330-386)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to APOBEC3C (probable DNA dC->dU-editing enzyme APOBEC-3C)


Catalog Number: (75930-248)
Supplier: Rockland Immunochemical
Description: NCBP1, also known as CBP80, is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. NCBP1 promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay (1,2). Recent evidence has shown that cellular-cap-binding proteins such as NCBP1 associate with influenza virus mRNAs, suggesting that these viral mRNAs may follow the normal cellular pathways for splicing, nuclear export, and translation (3).


Catalog Number: (10463-288)
Supplier: Bioss
Description: SAP 155 is a 1,304 amino acid member of the SF3B1 family and contains eleven HEAT repeats. Localized to nuclear speckles and also to the cytoplasm during mitosis, SAP 155 is a subunit of the SF3B splicing factor. The SF3B splicing factor is a U2 snRNP-associated protein complex essential for spliceosome assembly. SF3B contains the spliceosomal proteins SAP 49, SAP 130, SAP 145 and SAP 155. Concomitant with splicing catalysis, SAP 155 is phosphorylated at its N-terminal Thr-Pro dipeptide motifs by Dyrk1A and cyclin E/Cdk2. This modification of SAP 155 is vital for a functional spliceosome as it is an essential event in the basic splicing reaction. Due to alternative splicing events, various SAP 155 isoforms are produced.


Catalog Number: (89267-098)
Supplier: Genetex
Description: Rabbit polyclonal antibody to KIAA0460 (Middle)


Catalog Number: (103277-488)
Supplier: Novus Biologicals
Description: The SRp55 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SRp55. This antibody reacts with human, mouse. The SRp55 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (10093-826)
Supplier: Proteintech
Description: RNMT, also named as mRNA cap guanine-N7 methyltransferase or KIAA0398, is a 476 amino acid protein, which contains one mRNA cap 0 methyltransferase domain and belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. RNMT localizes in the nucleus and is widely expressed in various tissues. RNMT as a mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs and binds RNA containing 5'-terminal GpppC.


Catalog Number: (10071-904)
Supplier: Prosci
Description: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.


Catalog Number: (89270-638)
Supplier: Genetex
Description: Rabbit polyclonal antibody to SERBP1 (C-terminal)


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