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Anti-MSH2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10356-280)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Image Unavailable-10356-282

Anti-MSH2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10356-282)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Image Unavailable-10356-288

Anti-MSH2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10356-288)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Image Unavailable-MFLX32015-78

FRONT SHIELD

Catalog Number: (MFLX32015-78)
Supplier: AALBORG INSTRUMENTS & CONTROL
Description: FRONT SHIELD
Image Unavailable-10138-354

LIGHT SHIELD

Catalog Number: (10138-354)
Supplier: PERKINELMER U.S. LLC
Description: LIGHT SHIELD
Image Unavailable-77623-720

SPLASH SHIELD FOR E-52XX07C

Catalog Number: (77623-720)
Supplier: Ohaus
Description: SPLASH SHIELD FOR E-52XX07C

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Image Unavailable-77623-718

SPLASH SHIELD FOR E-G52XX07C

Catalog Number: (77623-718)
Supplier: Ohaus
Description: SPLASH SHIELD FOR E-G52XX07C

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Image Unavailable-101738-528

PROTEOTUNER SHIELD SYSTEM C

Catalog Number: (101738-528)
Supplier: Clontech Laboratories
Description: PROTEOTUNER SHIELD SYSTEM C
Image Unavailable-53880-074

SAFETY SHIELD MODEL C

Catalog Number: (53880-074)
Supplier: Carver
Description: SAFETY SHIELD MODEL C
Image Unavailable-MSPP-AST-4312

HEAT SHIELD BEARING

Catalog Number: (MSPP-AST-4312)
Supplier: ANGEL SCIENCE TECHNOLOGIES MS
Description: HEAT SHIELD BEARING
Image Unavailable-53880-076

SAFETY SHIELD MODEL M

Catalog Number: (53880-076)
Supplier: Carver
Description: SAFETY SHIELD MODEL M
Image Unavailable-89037-594

MEDIUM STRAIGHT SHIELD

Catalog Number: (89037-594)
Supplier: IBI Scientific
Description: MEDIUM STRAIGHT SHIELD
Image Unavailable-77662-036

DRIVEN GUARD SHIELD

Catalog Number: (77662-036)
Supplier: WORLD PRECISION INSTRUMENTS LLC
Description: DRIVEN GUARD SHIELD

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Image Unavailable-34330-936

ASSY WELDING SHIELD

Catalog Number: (34330-936)
Supplier: Draeger
Description: ASSY WELDING SHIELD
Product Image-98106-946

DISPENSER FACE MASK

Catalog Number: (98106-946)
Supplier: S-Curve Technologies
Description: DISPENSER FACE MASK
Image Unavailable-CGS-M-LN-24-NN

LAUNDRY - FACE MASK

Catalog Number: (CGS-M-LN-24-NN)
Supplier: CLEANROOM GARMENT SOLUTIONS SV
Description: LAUNDRY - FACE MASK
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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