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Catalog Number: (10451-660)
Supplier: Bioss
Description: The sub-membraneous region at the postsynaptic membrane contains a number of proteins critical for receptor targeting. Gephyrin is a microtubule-associated protein highly expressed in brain and localized to neuronal postsynaptic membranes. Gephyrin is essential for the postsynaptic localization of the inhibitory glycine receptor and is thought to anchor the receptor to subsynaptic microtubules. The protein is expressed in most mammalian tissues with predominant expression in brain. At least five additional splice variants of Gephyrin ranging in molecular weight have been identified in rat and human brain tissue.


Catalog Number: (10480-202)
Supplier: Bioss
Description: May forms part of a complex of membrane proteins attached to acetylcholinesterase (AChE).Tissue specificity:Ubiquitous. Widely expressed in brain.


Catalog Number: (10480-196)
Supplier: Bioss
Description: May forms part of a complex of membrane proteins attached to acetylcholinesterase (AChE).Tissue specificity:Ubiquitous. Widely expressed in brain.


Catalog Number: (103274-912)
Supplier: Novus Biologicals
Description: The smu1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to smu1. This antibody reacts with human, mouse, rat. The smu1 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.


Catalog Number: (75791-222)
Supplier: Prosci
Description: The MeCP2 helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout the body, although it is particularly abundant in brain cells.In the brain, the MeCP2 protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. The alternative splicing of proteins is critical for normal communication between neurons and may also be necessary for the function of other types of brain cells.


Catalog Number: (10070-080)
Supplier: Prosci
Description: SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons


Catalog Number: (10495-380)
Supplier: Bioss
Description: The downstream regulatory element, DRE, acts as a location-dependent gene silencer. DREAM (for DRE-antagonist modulator) is a Ca2+-regulated transcriptional repressor that specifically binds to the DRE. DREAM regulates transcription of prodynorphin and c-Fos genes and shows 99% nucleotide homology to the Kv channel-interacting proteins (KChIPs). KChIP family members include KChIP1, which is expressed in brain, KChIP2, which is expressed in heart, brain, and lung, KChIP3 (also designated calsenilin), which is expressed in brain and testis and KChIP4.


Catalog Number: (103282-448)
Supplier: Novus Biologicals
Description: The RHEBL1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to RHEBL1. This antibody reacts with human. The RHEBL1 Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.


Supplier: Electron Microscopy Sciences
Description: The TC-1 Tissue Chopper is designed to facilitate the cutting of 100 to 1000 micron thick brain tissue slices for use in recording experiments.

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Catalog Number: (76120-992)
Supplier: Bioss
Description: Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.


Catalog Number: (10335-174)
Supplier: Bioss
Description: Protein NDRG4 is a cytoplasmic protein that may play a role in the early postnatal development and function of neuronal cells. It may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined. Expressed only in brain and heart. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Belongs to the NDRG family.


Catalog Number: (103412-426)
Supplier: Novus Biologicals
Description: The Aldolase C Antibody (1A1) [DyLight 550] from Novus Biologicals is a mouse monoclonal antibody to Aldolase C. This antibody reacts with rat. The Aldolase C Antibody (1A1) [DyLight 550] has been validated for the following applications: Western Blot, Flow Cytometry, Immunocytochemistry / Immunofluorescence.


Catalog Number: (103412-430)
Supplier: Novus Biologicals
Description: The Aldolase C Antibody (1A1) [DyLight 680] from Novus Biologicals is a mouse monoclonal antibody to Aldolase C. This antibody reacts with rat. The Aldolase C Antibody (1A1) [DyLight 680] has been validated for the following applications: Western Blot, Flow Cytometry, Immunocytochemistry / Immunofluorescence.


Catalog Number: (76110-662)
Supplier: Bioss
Description: The downstream regulatory element, DRE, acts as a location-dependent gene silencer. DREAM (for DRE-antagonist modulator) is a Ca²⁺ regulated transcriptional repressor that specifically binds to the DRE. DREAM regulates transcription of prodynorphin and c-Fos genes and shows 99% nucleotide homology to the Kv channel-interacting proteins (KChIPs). KChIP family members include KChIP1, which is expressed in brain, KChIP2, which is expressed in heart, brain, and lung, KChIP3 (also designated calsenilin), which is expressed in brain and testis and KChIP4.


Catalog Number: (102988-408)
Supplier: Adipogen
Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM3 is the most abundant ganglioside in mammals. It is involved in several tumor processes by interacting with receptors. It inhibits epidermal cell growth and blocks insulin receptor activity.


Catalog Number: (76109-136)
Supplier: Bioss
Description: BRP44 is a 127 amino acid protein belonging to the UPF0041 family. The gene that encodes BRP44 maps to human chromosome 1, which is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.


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