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Catalog Number: (10751-086)

Supplier: Prosci

Description: CIITA Antibody: CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

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Catalog Number: (75791-726)

Supplier: Prosci

Description: Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1, EXT2, EXTL1, EXTL2, and EXTL3. Studies have shown that EXT gene family members have the activities of heparan sulfate-synthesizing glycosyltransferases. EXT1 and EXT2, which have been identified as causal genes for hereditary multiple exostoses, have HS-GlcAT-II and GlcNAcT-II activities. EXTL1 has GlcNAcT-II activity and EXTL3 has GlcNAcT-I and -II activities. EXTL2 has GlcNAcT-I and N-acetylgalactosaminyltransferase activities, and transfers a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation. In mice, lack of EXTL2 causes glycosaminoglycan (GAG) overproduction and structural changes of GAGs associated with pathological processes.

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Catalog Number: (220014-281)

Supplier: R&D Systems

Description: Anti-MIP-II Goat Polyclonal Antibody (Biotin)

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Catalog Number: (102173-108)

Supplier: Novus Biologicals

Description: Mouse Monoclonal MHC Class II Antibody (HIS19) [Biotin]. Tested Applications: Flow Cytometry. Tested Reactivity: Rat.

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Catalog Number: (77526-402)

Supplier: AFG BIOSCIENCE LLC

Description: Chicken COL2 (Collagen Type II) ELISA Kit

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Catalog Number: (ABCA_AB5131-50UG)

Supplier: ABCAM INC.

Description: Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) Rabbit Polyclonal Antibody

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Catalog Number: (77178-392)

Supplier: ANTIBODIES.COM LLC

Description: Recombinant rabbit monoclonal [TOP2A/8103R] antibody to Topoisomerase II alpha for IHC-P with samples derived from Human.

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Supplier: Strem Chemicals Inc

Description: P-PHOS

Catalog Number: (77513-344)

Supplier: AFG BIOSCIENCE LLC

Description: Human AGTR2 (Angiotensin II Receptor 2) ELISA Kit

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Supplier: Enzo Life Sciences

Description: Inhibitor of non-muscle myosin II

Catalog Number: (75841-446)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The M5/114.15.2 monoclonal antibody or (M5/114) is specific for the mouse major histocompatibility complex class II, specific for the I-A and I-E subregion-encoded glycoproteins (alloantigens I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek, but not the I-Af, I-Ak, nor I-As antigens). The antibody also reacts with cells from the H-2p or H-2r haplotypes mice. The polymorphic determinant represented by the mouse major histocompatibility complex class II (MHC Class II) is expressed by the immune cells bearing the specified alloantigens, like T and B lymphocytes, monocytes, dendritic cells, and macrophages. The antibody doesn’t react with the NOD H-2g7 haplotype alloantigens. M5/114 mAb inhibits I-A-restricted T cell responses of the Haplotypes H-2b, H-2d, H-2q, and H-2u.

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Catalog Number: (76121-046)

Supplier: Bioss

Description: Transcobalamin I (TCI) and Transcobalamin II (TCII) are secreted proteins belonging to the eukaryotic cobalamin transport proteins family and also to the vitamin B12-binding protein family. The genes encoding these proteins map to chromosome 11q11-q12 and 22q12.2, respectively. Transcobalamin I is a constituent of secondary granules in neutrophils, while Transcobalamin II binds cobalamin and mediates its transport into cells. These plasma proteins are expressed in various tissues and secretions.

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Supplier: Thermo Scientific Chemicals

Description: Pigment in white paints, UV absorber in plastics, ceramics, piezoelectric devices

SDS Certificates

Catalog Number: (10108-796)

Supplier: Prosci

Description: DNASE2B shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this protein is restricted to the salivary gland and lungs.The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.

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Supplier: MilliporeSigma

SDS

Catalog Number: (10106-552)

Supplier: Prosci

Description: C2ta is essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. C2ta may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter

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