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Description: SKAP2 (src kinase associated phosphoprotein 2), also named PRAP, contains PH domain and SH3 domain. It is localized in cytoplasm and was expressed in ubiquitously in various tissues including lung, skeletal muscle, and spleen, but not detectable in thymus and T cell lymphoma cells. SKAP2 may negatively regulate alpha-synuclein phosphorylation following cell stress. SKAP2 may be involved in B-cell and macrophage adhesion processes by coupling the B-cell receptor (BCR) to integrin activation.

Catalog Number: 10094-664

Supplier: Proteintech

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Description: Rabbit Polyclonal antibody to CTAG2

Catalog Number: 10162-062

Supplier: Genetex

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Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: SCAP2 antibody was raised against a 14 amino acid synthetic peptide near the C-Terminus of SCAP2; Application: ELISA, Western Blot

Catalog Number: 10116-672

Supplier: Prosci

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Description: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Catalog Number: 10667-282

Supplier: Bioss

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Description: The SETDB2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SETDB2. This antibody reacts with human. The SETDB2 Antibody has been validated for the following applications: Western Blot, Immunocytochemistry / Immunofluorescence, Immunoprecipitation.

Catalog Number: 102711-516

Supplier: Novus Biologicals

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Description: Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets. Siah2 triggers the ubiquitin-mediated degradation of many proteins, including transcription regulators (e.g. POU2AF1, PML, NCOR1), cell surface receptors (e.g. DCC), antiapoptotic proteins (e.g. BAG1), and proteins involved in synaptic vesicle function in neurons (e.g. SYP). Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.

Catalog Number: 10371-178

Supplier: Bioss

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Description: Get the most out of your Thermo Scientific™ microtome with this Thermo Scientific™ Specimen Clamp and Accessories.

Catalog Number: 16002-474

Supplier: Epredia

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Description: SATB1 Antibody: Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a 'cage-like' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a 'genome organizer' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.

Catalog Number: 10748-736

Supplier: Prosci

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Description: SATB1 Antibody: Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a 'cage-like' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a 'genome organizer' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.

Catalog Number: 10750-200

Supplier: Prosci

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Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Catalog Number: 10369-700

Supplier: Bioss

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Description: The SNTB2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SNTB2. This antibody reacts with human. The SNTB2 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.

Catalog Number: 102166-640

Supplier: Novus Biologicals

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Description: Stacking Kit for NB 4200 Series

Catalog Number: 89032-322

Supplier: Thermo Scientific

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Description: The Otubain-2 Antibody from Novus Biologicals is a goat polyclonal antibody to Otubain-2. This antibody reacts with human. The Otubain-2 Antibody has been validated for the following applications: Western Blot, Peptide ELISA.

Catalog Number: 102160-168

Supplier: Novus Biologicals

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Description: Anti-STAG1 Antibody, Host Species: Rabbit, Cross Reactivity: Human,Mouse,Rat, Immunogen: Recombinant Protein, 880-1221 amino acid, Format:Antigen affinity purification, Application: ELISA, WB, Recommended Storage: - 20 C or lower

Catalog Number: 10095-234

Supplier: Proteintech

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Description: The SCAP2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to SCAP2. This antibody reacts with human. The SCAP2 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.

Catalog Number: 102164-030

Supplier: Novus Biologicals

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Description: STAG3 is a meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.

Catalog Number: 10110-910

Supplier: Prosci

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