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Supplier: MASTERFLEX LLC
Description: Place motor and controller where convenient with modular design.

2 year warranty

Catalog Number: (10394-964)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.


Catalog Number: (10394-966)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.


Catalog Number: (MFLX31412-25)
Supplier: MIDWEST VALVE & FITTING INC
Description: Excellent choice to connect rigid tubing systems.


Supplier: SCAT AMERICAS, INC.
Description: These PFA / PTFE fittings connect SCAT SafetyCaps and SafetyWasteCaps to ensure that capillaries and tubes are sealed tightly.

Supplier: MASTERFLEX LLC
Description: Don’t lose control of your metering applications—digital display gives you precise control.

ISO9001 CE Compliant

Catalog Number: (10129-530)
Supplier: Upchurch Scientific
Description: IDEX Health and Science very high pressure (VHP) fittings are designed to withstand the extreme operating pressures of today's modern UHPLC systems


Supplier: Restek
Description: Ferrules are designed for use with micropacked columns, with a capillary design ideal for 1/16" compression-type fittings

Supplier: VWR International
Description: This 20 L system allows for the safe and effective collection of waste in the laboratory. The safety and ease of use for laboratory technicians is a high priority. The closed-loop design prevents inhalation of volatile organic componds.

Catalog Number: (10058-918)
Supplier: Restek
Description: The Swagelok® fitting kit includes the most common assortment of brass fittings for GC fixtures.


Supplier: MASTERFLEX LLC
Description: Built for bioprocess applications - designed for ease of use and process flexibility.

Supplier: MASTERFLEX LLC
Description: Maintenance-free drives built for precision dispensing.

IP66 washdown CE Compliant 2 year warranty

Supplier: Upchurch Scientific
Description: For higher pressure and temperature applications where a Flangeless connection is desired, consider the Flangeless SealTight™ Fitting System

Supplier: MASTERFLEX LLC
Description: Versatile variable-speed drive with a wide flow range and simple controls.

CE Compliant 2 year warranty

Supplier: Restek
Description: Combine the simplicity of a “Y” Press-Tight® connector with the strength of a metal union.

SDS

Supplier: MASTERFLEX LLC
Description: Complete systems to increase the efficiency and accuracy of filling and dispensing applications.

2 year warranty

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • State issued document with your organization's Federal Tax ID Number
  • State issued document with your organization's Resale Tax ID Number
  • City or County issued Business License
  • State Department of Health Services License
  • Any other ID issued by the State that includes the business name and address

* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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