Description: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

Catalog Number: 10352-772

Supplier: Bioss

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Description: It has been used in the synthesis of (1-ethyl-propyl)-[3-(4-methoxy-2-methylphenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl]-amine, in the synthesis of monoclinic VPO4·H2O, as internal standard in the screening of aziridine and 2-chloroethylamine in active pharmaceutical ingredients by gas chromatography-mass spectrometry.

Catalog Number: ALA133949100ML

Supplier: ALADDIN SCIENTIFIC

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Description: Polyclonal, Host: Goat; Target Species: Human; Immunogen: Syt5 antibody was raised against a 14 amino acid peptide near the internal region of Syt5 (aa 80-93); Applications: ELISA,Western blotting

Catalog Number: 10115-262

Supplier: Prosci

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Description: Bead beating is the most effective and verstile lysis method available.

Catalog Number: 10032-368

Supplier: OMNI INTERNATIONAL

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Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: FAM62A antibody was raised against a 13 amino acid synthetic peptide near the internal region of FAM62A; Application: ELISA, Western Blot

Catalog Number: 10116-990

Supplier: Prosci

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Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: CAGE1 antibody was raised against a 15 amino acid synthetic peptide near the internal region of CAGE1, Tested Applications: ELISA, WB

Catalog Number: 10114-112

Supplier: Prosci

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Description: Polyclonal, Host: Goat; Target Species: Human; Immunogen: GPRIN3 antibody was raised against a 10 amino acid synthetic peptide near the internal region of GPRIN3; Applications: ELISA,Western blotting

Catalog Number: 10114-954

Supplier: Prosci

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Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: SLC6A4 antibody was raised against an 11 amino acid synthetic peptide near the internal region of SLC6A4; Application: ELISA, Western Blot

Catalog Number: 10116-732

Supplier: Prosci

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Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: ABCA9 antibody was raised against a 14 amino acid synthetic peptide near the internal region of ABCA9; Application: ELISA, Western Blot

Catalog Number: 10117-222

Supplier: Prosci

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Description: Polyclonal, Host: Goat; Target Species: Human; Immunogen: DAG1 antibody was raised against a 14 amino acid synthetic peptide near the internal region of DAG1; Applications: ELISA,Western blotting

Catalog Number: 10114-672

Supplier: Prosci

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Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: ABCC1 antibody was raised against a 15 amino acid synthetic peptide near the internal region of ABCC1; Application: ELISA, Western Blot

Catalog Number: 10117-226

Supplier: Prosci

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Description: Polyclonal, Host: Goat; Target Species: Rat; Immunogen: cyp1a1 Antibody was raised against a 15 amino acid sequence near the internal region of cyp1a1 (mouse); Applications: ELISA,Western blotting

Catalog Number: 10115-076

Supplier: Prosci

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Description: Polyclonal, Host: Goat; Target Species: Human; Immunogen: DACH1 antibody was raised against a 13 amino acid synthetic peptide near the internal region of DACH1; Applications: ELISA,Western blotting

Catalog Number: 10114-846

Supplier: Prosci

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Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: DEPDC4 antibody was raised against a 12 amino acid synthetic peptide near the internal region of DEPDC4, Tested Applications: ELISA, WB

Catalog Number: 10114-114

Supplier: Prosci

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Description: Polyclonal antibody MAN2A1 Host: Goat Target Species: human immunogen: MAN2A1 antibody was raised against an 11 amino acid synthetic peptide near the internal region of MAN2A1. Application: ELISA

Catalog Number: 10116-270

Supplier: Prosci

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Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: GALNS antibody was raised against a 12 amino acid synthetic peptide near the internal region of GALNS; Application: ELISA, Western Blot

Catalog Number: 10116-998

Supplier: Prosci

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