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Product Image-75784-236

Cap Inserts for Cryogenic Vials, Globe Scientific

Supplier: Globe Scientific
Description: Produced from polypropylene, cap inserts are available in assorted colors and are ideal for color coding and sample identification

Image Unavailable-10399-456

Anti-ACKR3 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10399-456)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
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Anti-ACKR3 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10399-452)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Image Unavailable-10452-304

Anti-KCNJ3 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10452-304)
Supplier: Bioss
Description: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Product Image-89418-290

Anti-CLDN4 Rabbit Polyclonal Antibody

Catalog Number: (89418-290)
Supplier: Prosci
Description: CLAUDIN4 Antibody: CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.
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Anti-KCNJ3 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10452-302)
Supplier: Bioss
Description: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Image Unavailable-10425-600

Anti-SLC9A3R1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10425-600)
Supplier: Bioss
Description: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
Image Unavailable-75791-384

Mouse Recombinant Apolipoprotein E

Catalog Number: (75791-384)
Supplier: Prosci
Description: Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. APOE is usually secreted in plasma. Phosphorylation sites are present in the extracellular medium.
Product Image-14231-232

Superlite Folding Truck, Wesco International

Catalog Number: (14231-232)
Supplier: Wesco
Description: Space saving folding design. Fits in to small storage spaces or car trunks.
Product Image-76017-666

Mini Electric Scissors Lift Table, MELT, Wesco International

Catalog Number: (76017-666)
Supplier: Wesco
Description: Heavy duty to handle tough loads.
Product Image-10853-034

RESQ-Med™ Holster Set, Emergency Medical International

Catalog Number: (10853-034)
Supplier: EMI - Emergency Medical International
Description: RESQ-Med™ is the ultimate response holster set.
Image Unavailable-75790-136

Human Recombinant CD79B (from Cells)

Catalog Number: (75790-136)
Supplier: Prosci
Description: CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR), which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79B enhances phosphorylation of CD79A, possibly by recruiting kinases that phosphorylate CD79A or by recruiting proteins that bind to CD79A and protect it from dephosphorylation.
Image Unavailable-76100-542

Anti-Syndetin Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)

Catalog Number: (76100-542)
Supplier: Bioss
Description: Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Product Image-75997-438

Supermax Robust™ Blue Nitrile Gloves

Supplier: SUPERMAX HEALTHCARE INC
Description: Aurelia Robust Blue Nitrile Powder Free Examination Gloves are made from our special nitrile (NBR) compound, protein free (non-latex), ambidextrous and non sterile.Each batch of gloves is air-tested to detect pinholes. Aurelia gloves conform and are tested to the highest international standards.

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Abz-Ser-Pro-3-nitro-Tyr-OH

Supplier: Bachem Americas
Description: Selective substrate for angiotensin-converting enzyme 2 (ACE2), an ACE homolog which differs in its specificity and physiological role from ACE. The internally quenched fluorescent (FRET) substrate is potentially useful in applications such as high-throughput screening of ACE2 inhibitors (Km = 23 µM, kcat/Km = 3.5 · 10⁴ M⁻¹s⁻¹).

Product Image-TWTX757E

CleanTips® Micro CleanFoam® ESD Swab, Texwipe®

Catalog Number: (TWTX757E)
Supplier: Texwipe
Description: The Micro CleanFoam® ESD Swab is an excellent dissipative swab for cleaning very small areas
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • State issued document with your organization's Federal Tax ID Number
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  • City or County issued Business License
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  • Any other ID issued by the State that includes the business name and address

* Please note if your account is within the State of California two of these pieces of identification will be required.
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-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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