You Searched For: Heat+Block

Supplier: Adipogen

Description: Verapamil hydrochloride is an alpha-adrenergic receptor (alpha-AR) antagonist and calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein). Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models. Verapamil helps treat diabetes by limiting TXNIP expression.

Catalog Number: (10279-248)

Supplier: Bioss

Description: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model.

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Supplier: Techcon Systems

Description: Premium syringe barrels are available in four colors

Supplier: Showa

Description: Offer hand protection when working with sharp or abrasive materials including glass, sheet metal, scrap metal, tin plate, lumber, concrete block, and tile.

Catalog Number: (95040-484)

Supplier: Enzo Life Sciences

Description: Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

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Supplier: Bachem Americas

Description: ω-Conotoxin GVIA from the venom of the fish-hunting cone snail Conus geographus efficiently blocks neuronal calcium channels. This presynaptic inhibition of calcium influx prevents the voltage-activated release of acetylcholine.

Supplier: National Marker

Description: Fire extinguisher signs indicate the locations of required fire suppression equipment around the facility.

Catalog Number: (89361-238)

Supplier: Genetex

Description: Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and ~7. For example, XIAP, cIAP 1 and cIAP 2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP 1 and cIAP 2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.

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Supplier: Biolegend

Description: Ultra-LEAF™ Purified anti-mouse CD210 (IL-10 R) [1B1.3a]; Isotype: Rat IgG1, κ; Reactivity: Mouse; Apps: FC, Block; Size: 1 mg

Catalog Number: (102407-834)

Supplier: Bulldog Bio

Description: For precise control of speed and temperature in a small package, the BioShake iQ has no equal. Boasting the same established mixing mechanics utilized in all BioShake units, the BioShake iQ adds the feature of full thermal control over the shaking samples. The unit is housed in a conveniently small footprint, no bigger than two microplates placed side by side, and delivers well-blended samples in a variety of vessels including microplates, tubes, and vials.

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Supplier: Adipogen

Description: Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

Supplier: Biolegend

Description: Ultra-LEAF™ Purified anti-human CD154 [24-31]; Isotype: Mouse IgG1, κ; Reactivity: Human, Cross-Reactivity: Cynomolgus, Rhesus; Apps: FC, Block, IF; Size: 1 mg

Catalog Number: (102552-942)

Supplier: BioVendor

Description: Total 111 AA. MW: 12.0 kDa (calculated). UniProtKB acc.no. P61604. N-Terminal His-tag (10 extra AA).

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Catalog Number: (77439-964)

Supplier: Bioss

Description: The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].

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Catalog Number: (89361-276)

Supplier: Genetex

Description: Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and ~7. For example, XIAP, cIAP 1 and cIAP 2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP 1 and cIAP 2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.

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Supplier: New England Biolabs (NEB)

Description: Blocking of the 3´ -hydroxyl of m7G with 3´-0-Me assures that the capped transcripts are homogeneous