You Searched For: Heat+Block

Catalog Number: (76329-820)

Supplier: IKA Works

Description: The myPlate magnetic stirrer has similar technical features to the popular colour squid and big squid magnetic stirrers together with the option of creative individualisation. The interchangeable personal frame allows you to design the set-up plate of the myPlate by yourself.

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Catalog Number: (76481-772)

Supplier: AAT BIOQUEST INC

Description: FMOC-Glu(TQ3)-OH is a building block for in-sequence Lys labeling by Tide Quencher™ 3 (TQ3).

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Catalog Number: (10282-230)

Supplier: Bioss

Description: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].

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Catalog Number: (10088-354)

Supplier: Proteintech

Description: Heme oxygenase (HMOX1) catalyzes the first and rate-limiting step in the degradation of heme to yield equimolar quantities of biliverdin Ixa, carbon monoxide (CO), and iron .It has 3 isoforms:HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed.Heme oxygenase-1 (HO-1) is expressed in many tissues and vascular smooth muscle cells, and endothelial cellsand has been identified as an important endogenous protective factor induced in many cell types by various stimulants, such as hemolysis, infiammatory cytokines,oxidative stress, heat shock, heavy metals, and endotoxin. And the full-length HO-1 is very unstable and susceptible to truncation that generates an inactive, soluble form (28 kDa)(James R. Reed,Pharmacology ,535-568).

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Catalog Number: (76481-314)

Supplier: AAT BIOQUEST INC

Description: An amine-reactive building block for developing a probe that can be recognized by anti-DNP antibodies; Also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

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Catalog Number: (25608-942)

Supplier: Sakura Finetek

Description: Use for chilling and preparing paraffin blocks for microtome sectioning also as cold tray for other lab procedures.

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Supplier: Safety & Industrial Supplies

Description: Lenses made of polycarbonate block 100% of harmful UV Radiation.

New Product

Supplier: Contec

Description: Polynit Heatseal Wipes are made of 100% knitted polyester that is laser cut to bond the fibers at the edges of the wipe. This creates a very clean, non-abrasive edge that allows full utilization of the wipe surface.

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Supplier: Electron Microscopy Sciences

Description: These stainless steel chucks are designed to be used cold for rapid freezing, and to maximize the gripping power required to hold the embedded tissue block. The stem of the chuck provides the focal point for a sharp tap resulting in an easily release of the block from the well. These chucks fit many of the major brand cryostat and can be used in most cryostats with use of an adapter. These Chuck Adapters have stem measures 20mm L x 9mm diameter, and fit Leica and most Microm cryostats. We also offer adapters to use these chuck for other cryostats.

Catalog Number: (10462-468)

Supplier: Bioss

Description: The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. The proteins contain cysteine rich regions that are composed of zinc fingers that form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJB2 (DnaJ homolog subfamily B member 2), also known as HSJ1 or HSPF3, is expressed almost exclusively in the brain, with the highest levels in the frontal cortex and hippocampus. Two isoforms are produced due to alternative splicing.

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Catalog Number: (10462-470)

Supplier: Bioss

Description: The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. The proteins contain cysteine rich regions that are composed of zinc fingers that form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJB2 (DnaJ homolog subfamily B member 2), also known as HSJ1 or HSPF3, is expressed almost exclusively in the brain, with the highest levels in the frontal cortex and hippocampus. Two isoforms are produced due to alternative splicing.

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Catalog Number: (89419-198)

Supplier: Prosci

Description: IL-27 peptide is used for blocking activity of IL-27 antibody.

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Catalog Number: (10426-112)

Supplier: Bioss

Description: The cyclophilins are a conserved class of proteins that bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. CsA blocks helper T-cell activation at a step between T-cell receptor stimulation and the transcriptional activation of cytokine genes. Cyclophilins from many species possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that is blocked by CsA and therefore may be relevant in CsA-mediated immunosuppression.

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Catalog Number: (RLK-500)

Supplier: Rockland Immunochemical

Description: Antibody starter pack contains key reagents necessary to perform ELISA, immunohistochemistry, and immunofluorescence. Included are antibodies suitable for ELISA, immunohistochemistry, immunoprecipitation, immunofluorescent microscopy, and western blotting.

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Catalog Number: (10423-432)

Supplier: Bioss

Description: BAG5 is a member of the BAG1 related protein family. BAG1 is an anti apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL 2, Raf protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. A BAG domain near the C terminus, may bind and inhibit the chaperone activity of Hsc70/Hsp70. It has been hypothesized that the BAG5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70’s anti apoptotic function. It is believed that BAG5 will play an important role in the mechanisms of neuronal death. BAG5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/modulation of other BAG containing proteins via BAG-BAGheterodimerization.

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Catalog Number: (102251-190)

Supplier: Novus Biologicals

Description: Mouse Monoclonal GRO2 Antibody (MM0214-11B27). Tested Applications: Western Blot, Blocking/Neutralizing. Tested Reactivity: Human.

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