You Searched For: Heat+Block

Catalog Number: (10287-494)

Supplier: Bioss

Description: The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. The proteins contain cysteine rich regions that are composed of zinc fingers that form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJA2 (DnaJ homolog subfamily A member 2), also known as HIRA-interacting protein 4 or cell cycle progression restoration gene 3 protein, contains one CR-type zinc finger and is a co-chaperone of HSC 70.

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Supplier: Safety & Industrial Supplies

Description: Twin cup design minimizes resonance, thus achieving maximum high and low frequency attenuation.

Supplier: Biotium

Description: This antibody recognizes a 24-27 kDa estrogen-regulated protein, identified as heat shock protein 27 (hsp27). Hsp27 was recently found to be identical to the estrogen-induced p29 and 24K protein. About 50% of breast carcinomas are positive for hsp27 especially those that are also positive for estrogen and/or progesterone receptor. HSP27 has also been implicated in drug resistance in cancer cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Bachem Americas

Description: Guanylin and uroguanylin are structurally related peptides which act on a transmembrane form of guanylate cyclase, termed GC-C. In mammals, they play pivotal roles in body fluid homeostasis. Less well defined additional members belonging to this family were identified in opposum and in eel.

Catalog Number: (10663-888)

Supplier: Bioss

Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008].

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Catalog Number: (10338-964)

Supplier: Bioss

Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

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Supplier: RDA CONTAINER CORPORATION SE

Description: Educational Materials, Wooden Block

Supplier: Spectrum Chemicals

Description: Acesulfame Potassium, NF is a white crystallized powder. 

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Catalog Number: (99990-084)

Supplier: Diagnostic Biosystems

Description: To reduce nonspecific staining during IHC.

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Catalog Number: (103286-810)

Supplier: Novus Biologicals

Description: The HSP10 / EPF Antibody from Novus Biologicals is a rabbit polyclonal antibody to HSP10 / EPF. This antibody reacts with human. The HSP10 / EPF Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.

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Catalog Number: (103328-612)

Supplier: Novus Biologicals

Description: The HspA1L Antibody (1B5) from Novus Biologicals is a mouse monoclonal antibody to HspA1L. This antibody reacts with human, rat. The HspA1L Antibody (1B5) has been validated for the following applications: Western Blot, ELISA.

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Catalog Number: (103281-750)

Supplier: Novus Biologicals

Description: The HSP27 Antibody (G3.1) - IHC-Prediluted from Novus Biologicals is a mouse monoclonal antibody to HSP27. This antibody reacts with human, mouse, rat, chicken, primate, sheep. The HSP27 Antibody (G3.1) - IHC-Prediluted has been validated for the following applications: Immunohistochemistry-Paraffin.

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Supplier: Surmodics

Description: StabilCoat® Immunoassay Stabilizer 5X concentrate, effectively preserves the conformation and activity of dried proteins while simultaneously blocking the surface to reduce non-specific binding. The product can be used to stabilize antibodies, antigens or enzymes on an assortment of immunoassay components including polystyrene plates, tubes, glass, membranes, and filter paper.

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Catalog Number: (33200-000)

Supplier: Elvex

Description: Dielectric, comfortable, lightweight muff at an economical price

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Catalog Number: (200062-418)

Supplier: Enzo Life Sciences

Description: Cleavage of heme b (Fe-protoporphyrin IX) at the a-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species, biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway represents the only efficient way of making bilirubin and thereby deterring activation of oxygen by the heme molecule. HO-1 belongs to the heat shock protein family (Hsp32), while HO-2 takes a constitutive form expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process carry out important physiological activities. CO may act as a messenger in the brain and systemic organs stimulating cGMP-production through interactions with the heme-dependent form of guanylate cyclase. Bile pigments display potent antioxidant activity as well as effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity, apparently a result of post translational modifications. In rat, the enzyme also shows a tissue specific developmental pattern. BVR is not inactivated by heat shock, and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, reductase preserves microheterogeneity under thermal stress. BVR expression occurs not only in cells and brain regions that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. Rat cDNA for BVR has been isolated and characterized. The deduced protein contains 3 cysteine residues (Cys73, Cys281, and Cys290) involved in cofactor and substrate binding. Human BVR consists of a substantially longer polypeptide than the rat enzyme (41-42 kDa vs. 33 kDa), but also is dual cofactor and dual pH dependent, requires free SH groups for activity, and displays pI and molecular mass microheterogeneity. The human and rat BVR share some antigenic epitopes and show immunochemical cross reactivity.

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Supplier: GE Healthcare - HyClone

Description: Defined foetal bovine serum (FBS) is the highest quality of FBS available and is very widely used by those cell culturist who have a concern for viral contaminants and require an extensive biochemical profile. Defined FBS is filtered through multiple 40 nm (0.04 µm) pore-size related filters, which are the most retentive filters used in commercial FBS production. Over 50 components are analysed and the results are included on the biochemical assay.

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